Exacerbated mechanical allodynia in rats with depression-like behavior

Abstract Although a clinical connection between pain and depression has long been recognized, how these two conditions interact remains unclear. Here we report that both mechanical allodynia and depression-like behavior were significantly exacerbated after peripheral nerve injury in Wistar-Kyoto (WK...

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Veröffentlicht in:Brain research 2008-03, Vol.1200, p.27-38
Hauptverfasser: Zeng, Qing, Wang, Shuxing, Lim, Grewo, Yang, Liling, Mao, Ji, Sung, Backil, Chang, Yang, Lim, Jeong-Ae, Guo, Gongshe, Mao, Jianren
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Sprache:eng
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Zusammenfassung:Abstract Although a clinical connection between pain and depression has long been recognized, how these two conditions interact remains unclear. Here we report that both mechanical allodynia and depression-like behavior were significantly exacerbated after peripheral nerve injury in Wistar-Kyoto (WKY) rats, a genetic variation of Wistar rats with demonstrable depression-like behavior. Administration of melatonin into the anterior cingular cortex contralateral to peripheral nerve injury prevented the exacerbation of mechanical allodynia with a concurrent improvement of depression-like behavior in WKY rats. Moreover, there was a lower plasma melatonin concentration and a lower melatonin receptor expression in the anterior cingular cortex in WKY rats than in Wistar rats. These results suggest that there exists a reciprocal relationship between mechanical allodynia and depression-like behavior and the melatoninergic system in the anterior cingular cortex might play an important role in the interaction between pain and depression.
ISSN:0006-8993
1872-6240
DOI:10.1016/j.brainres.2008.01.038