Sclerosing Epithelioid Fibrosarcoma: Case Presentation and a Systematic Review
In sclerosing epithelioid fibrosarcoma (SEF), a rare variant of low-grade fibrosarcoma, treatment results and therapeutic options are poorly characterized. We systematically analyzed the data of all 89 patients (43 female, 46 male; mean age, 47 years [range, 14–87 years]) reported in the literature...
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| Veröffentlicht in: | Clinical orthopaedics and related research 2008-06, Vol.466 (6), p.1485-1491 |
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| description | In sclerosing epithelioid fibrosarcoma (SEF), a rare variant of low-grade fibrosarcoma, treatment results and therapeutic options are poorly characterized. We systematically analyzed the data of all 89 patients (43 female, 46 male; mean age, 47 years [range, 14–87 years]) reported in the literature concerning clinical presentation, histopathology, differential diagnosis, treatment, survival rates, and prognosis, and we present an additional case. Information detailing treatment, disease control, and followup was available in 60 (67%), 75 (84%), and 68 patients (76%), respectively. Case history was variable with one-third of patients reporting a painful, enlarging mass. Ten patients (13%) presented with metastases, 23 (31%) had metastases develop after diagnosis, and 28 (37%) had local recurrence. Low cellularity, mild pleomorphy, and sclerotic hyaline matrix of SEF suggest a benign clinical behavior, and cell morphology allows for the wide differential diagnosis of benign, pseudosarcomatous, and malignant proliferations. In addition to surgery, 11 patients (15%) had chemotherapy, 22 (29%) had postoperative radiation therapy, and three (4%) had a combination of both. Twenty-three patients (34%) died from their disease after a mean of 46 months, 24 (35%) were alive with disease, and 20 (31%) were alive without evidence of disease. Patients with SEF of the head and neck had the worst prognosis.
Level of Evidence:
Level III, prognostic study. See the Guidelines for Authors for a complete description of levels of evidence. |
| doi_str_mv | 10.1007/s11999-008-0205-8 |
| format | Article |
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Level of Evidence:
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Level of Evidence:
Level III, prognostic study. 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We systematically analyzed the data of all 89 patients (43 female, 46 male; mean age, 47 years [range, 14–87 years]) reported in the literature concerning clinical presentation, histopathology, differential diagnosis, treatment, survival rates, and prognosis, and we present an additional case. Information detailing treatment, disease control, and followup was available in 60 (67%), 75 (84%), and 68 patients (76%), respectively. Case history was variable with one-third of patients reporting a painful, enlarging mass. Ten patients (13%) presented with metastases, 23 (31%) had metastases develop after diagnosis, and 28 (37%) had local recurrence. Low cellularity, mild pleomorphy, and sclerotic hyaline matrix of SEF suggest a benign clinical behavior, and cell morphology allows for the wide differential diagnosis of benign, pseudosarcomatous, and malignant proliferations. In addition to surgery, 11 patients (15%) had chemotherapy, 22 (29%) had postoperative radiation therapy, and three (4%) had a combination of both. Twenty-three patients (34%) died from their disease after a mean of 46 months, 24 (35%) were alive with disease, and 20 (31%) were alive without evidence of disease. Patients with SEF of the head and neck had the worst prognosis.
Level of Evidence:
Level III, prognostic study. See the Guidelines for Authors for a complete description of levels of evidence.</abstract><cop>New York</cop><pub>Springer-Verlag</pub><pmid>18340502</pmid><doi>10.1007/s11999-008-0205-8</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Aged Aged, 80 and over Biological and medical sciences Bone Neoplasms - diagnostic imaging Bone Neoplasms - pathology Bone Neoplasms - therapy Conservative Orthopedics Diseases of the osteoarticular system Female Fibrosarcoma - diagnostic imaging Fibrosarcoma - pathology Fibrosarcoma - therapy Humans Male Medical sciences Medicine Medicine & Public Health Middle Aged Orthopedics Radiography Sports Medicine Surgery Surgical Orthopedics Survey Ulna |
| title | Sclerosing Epithelioid Fibrosarcoma: Case Presentation and a Systematic Review |
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