BBP-Mud2p heterodimer mediates branchpoint recognition and influences splicing substrate abundance in budding yeast

The 3' end of mammalian introns is marked by the branchpoint binding protein, SF1, and the U2AF65-U2AF35 heterodimer bound at an adjacent sequence. Baker's yeast has equivalent proteins, branchpoint binding protein (BBP) (SF1) and Mud2p (U2AF65), but lacks an obvious U2AF35 homolog, leavin...

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Veröffentlicht in:	Nucleic acids research 2008-05, Vol.36 (8), p.2787-2798
Hauptverfasser:	Wang, Qiang, Zhang, Li, Lynn, Bert, Rymond, Brian C
Format:	Artikel
Sprache:	eng
Schlagworte:	Dimerization DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Gene Deletion Molecular Biology Ribonucleoproteins - genetics Ribonucleoproteins - metabolism RNA Precursors - metabolism RNA Splicing RNA Splicing Factors RNA, Messenger - metabolism Saccharomyces cerevisiae Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism Splicing Factor U2AF Suppression, Genetic Transcription Factors - genetics Transcription Factors - metabolism Two-Hybrid System Techniques
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