Quinazoline-based α1-adrenoceptor antagonists induce prostate cancer cell apoptosis via TGF-β signalling and IκBα induction

Previous studies documented the ability of quinazoline-based α 1-adrenoceptor antagonists to induce apoptosis in prostate cancer cells via an α 1-adrenoceptor-independent mechanism. In this study we investigated the molecular events initiating this apoptotic effect. Since transforming growth factor-...

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Veröffentlicht in:	British journal of cancer 2003-05, Vol.88 (10), p.1615-1621
Hauptverfasser:	Partin, J V, Anglin, I E, Kyprianou, N
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer Research Drug Resistance Epidemiology Experimental Therapeutics General aspects Medical sciences Molecular Medicine Oncology Pharmacology. Drug treatments
Online-Zugang:	Volltext
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