Activation of the Epstein–Barr virus lytic cycle by the latex of the plant Euphorbia tirucalli
Exposure to the plant Euphorbia tirucalli has been proposed to be a cofactor in the genesis of endemic Burkitt's lymphoma (eBL). The purpose of this study was to examine the effects of unpurified E. tirucalli latex on Epstein–Barr virus (EBV) gene expression. A Burkitt lymphoma cell line was tr...
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| Veröffentlicht in: | British journal of cancer 2003-05, Vol.88 (10), p.1566-1569 |
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| creator | MacNeil, A Sumba, O P Lutzke, M L Moormann, A Rochford, R |
| description | Exposure to the plant
Euphorbia tirucalli
has been proposed to be a cofactor in the genesis of endemic Burkitt's lymphoma (eBL). The purpose of this study was to examine the effects of unpurified
E. tirucalli
latex on Epstein–Barr virus (EBV) gene expression. A Burkitt lymphoma cell line was treated with varying dilutions of the latex and the effects on EBV gene expression were measured. We observed that the latex was capable of reactivating the EBV lytic cycle in a dose-dependent manner and at dilutions as low as 10
−6
. Simultaneous treatment of cells with
E. tirucalli
latex and the protein kinase C inhibitor 1-(5-isoquinolinesulphonyl)-2-methylpiperazine dihydrochloride blocked lytic cycle activation. These data suggest that environmental exposure to the latex of
E. tirucalli
could directly activate the EBV lytic cycle and provide further evidence of a role for
E. tirucalli
in the aetiology of eBL. |
| doi_str_mv | 10.1038/sj.bjc.6600929 |
| format | Article |
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Euphorbia tirucalli
has been proposed to be a cofactor in the genesis of endemic Burkitt's lymphoma (eBL). The purpose of this study was to examine the effects of unpurified
E. tirucalli
latex on Epstein–Barr virus (EBV) gene expression. A Burkitt lymphoma cell line was treated with varying dilutions of the latex and the effects on EBV gene expression were measured. We observed that the latex was capable of reactivating the EBV lytic cycle in a dose-dependent manner and at dilutions as low as 10
−6
. Simultaneous treatment of cells with
E. tirucalli
latex and the protein kinase C inhibitor 1-(5-isoquinolinesulphonyl)-2-methylpiperazine dihydrochloride blocked lytic cycle activation. These data suggest that environmental exposure to the latex of
E. tirucalli
could directly activate the EBV lytic cycle and provide further evidence of a role for
E. tirucalli
in the aetiology of eBL.</description><identifier>ISSN: 0007-0920</identifier><identifier>EISSN: 1532-1827</identifier><identifier>DOI: 10.1038/sj.bjc.6600929</identifier><identifier>PMID: 12771923</identifier><identifier>CODEN: BJCAAI</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Biological and medical sciences ; Biomedical and Life Sciences ; Biomedicine ; Burkitt Lymphoma - physiopathology ; Burkitt Lymphoma - virology ; Cancer Research ; Drug Resistance ; Environmental Exposure ; Epidemiology ; Epstein-Barr virus ; Euphorbia - virology ; Gene expression ; Gene Expression Regulation ; Hematologic and hematopoietic diseases ; Herpesvirus 4, Human - pathogenicity ; Humans ; Kinases ; Latex - chemistry ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Lymphoma ; Malaria ; Medical research ; Medical sciences ; Molecular and Cellular Pathology ; Molecular Medicine ; Oncology ; Tumor Cells, Cultured</subject><ispartof>British journal of cancer, 2003-05, Vol.88 (10), p.1566-1569</ispartof><rights>The Author(s) 2003</rights><rights>2003 INIST-CNRS</rights><rights>Copyright Nature Publishing Group May 19, 2003</rights><rights>Copyright © 2003 Cancer Research UK 2003 Cancer Research UK</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c483t-5fa518ec53b3c554867a688c2229bc950a671889dffd286f8fb3251facfe28b03</citedby><cites>FETCH-LOGICAL-c483t-5fa518ec53b3c554867a688c2229bc950a671889dffd286f8fb3251facfe28b03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2377104/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2377104/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27923,27924,41487,42556,51318,53790,53792</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14802587$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12771923$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MacNeil, A</creatorcontrib><creatorcontrib>Sumba, O P</creatorcontrib><creatorcontrib>Lutzke, M L</creatorcontrib><creatorcontrib>Moormann, A</creatorcontrib><creatorcontrib>Rochford, R</creatorcontrib><title>Activation of the Epstein–Barr virus lytic cycle by the latex of the plant Euphorbia tirucalli</title><title>British journal of cancer</title><addtitle>Br J Cancer</addtitle><addtitle>Br J Cancer</addtitle><description>Exposure to the plant
Euphorbia tirucalli
has been proposed to be a cofactor in the genesis of endemic Burkitt's lymphoma (eBL). The purpose of this study was to examine the effects of unpurified
E. tirucalli
latex on Epstein–Barr virus (EBV) gene expression. A Burkitt lymphoma cell line was treated with varying dilutions of the latex and the effects on EBV gene expression were measured. We observed that the latex was capable of reactivating the EBV lytic cycle in a dose-dependent manner and at dilutions as low as 10
−6
. Simultaneous treatment of cells with
E. tirucalli
latex and the protein kinase C inhibitor 1-(5-isoquinolinesulphonyl)-2-methylpiperazine dihydrochloride blocked lytic cycle activation. These data suggest that environmental exposure to the latex of
E. tirucalli
could directly activate the EBV lytic cycle and provide further evidence of a role for
E. tirucalli
in the aetiology of eBL.</description><subject>Biological and medical sciences</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Burkitt Lymphoma - physiopathology</subject><subject>Burkitt Lymphoma - virology</subject><subject>Cancer Research</subject><subject>Drug Resistance</subject><subject>Environmental Exposure</subject><subject>Epidemiology</subject><subject>Epstein-Barr virus</subject><subject>Euphorbia - virology</subject><subject>Gene expression</subject><subject>Gene Expression Regulation</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Herpesvirus 4, Human - pathogenicity</subject><subject>Humans</subject><subject>Kinases</subject><subject>Latex - chemistry</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Lymphoma</subject><subject>Malaria</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Molecular and Cellular Pathology</subject><subject>Molecular Medicine</subject><subject>Oncology</subject><subject>Tumor Cells, Cultured</subject><issn>0007-0920</issn><issn>1532-1827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kc9O3DAQxi1UBAvtlSOyKnHM4j_rZHJBomihSEhc6Nl1vDbrKCTBdlbdG-_AG_IkuN3QhQMnazy_b-bTfAgdUTKlhMNpqKdVrad5TkjJyh00oYKzjAIrvqAJIaTI0j_ZRwch1KksCRR7aJ-yoqAl4xP0-1xHt1LRdS3uLI5Lg-d9iMa1L0_PP5T3eOX8EHCzjk5jvdaNwdX6H9eoaP68ifpGtRHPh37Z-copHJNKq6ZxX9GuVU0w38b3EP26nN9d_Mxubq-uL85vMj0DHjNhlaBgtOAV10LMIC9UDqAZY2WlS0FUXlCAcmHtgkFuwVacCWqVtoZBRfghOtvM7YfqwSy0aaNXjey9e1B-LTvl5MdO65byvltJxtMtyCwN-D4O8N3jYEKUdTf4NnmWyUMJADRP0HQDad-F4I39v4AS-TcQGWqZApFjIElw_N7WFh8TSMDJCKiQDma9arULW24GhAkoEne64UJqtffGb-19svoV50ymuQ</recordid><startdate>20030519</startdate><enddate>20030519</enddate><creator>MacNeil, A</creator><creator>Sumba, O P</creator><creator>Lutzke, M L</creator><creator>Moormann, A</creator><creator>Rochford, R</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope></search><sort><creationdate>20030519</creationdate><title>Activation of the Epstein–Barr virus lytic cycle by the latex of the plant Euphorbia tirucalli</title><author>MacNeil, A ; Sumba, O P ; Lutzke, M L ; Moormann, A ; Rochford, R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c483t-5fa518ec53b3c554867a688c2229bc950a671889dffd286f8fb3251facfe28b03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Biological and medical sciences</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Burkitt Lymphoma - physiopathology</topic><topic>Burkitt Lymphoma - virology</topic><topic>Cancer Research</topic><topic>Drug Resistance</topic><topic>Environmental Exposure</topic><topic>Epidemiology</topic><topic>Epstein-Barr virus</topic><topic>Euphorbia - virology</topic><topic>Gene expression</topic><topic>Gene Expression Regulation</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Herpesvirus 4, Human - pathogenicity</topic><topic>Humans</topic><topic>Kinases</topic><topic>Latex - chemistry</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Lymphoma</topic><topic>Malaria</topic><topic>Medical research</topic><topic>Medical sciences</topic><topic>Molecular and Cellular Pathology</topic><topic>Molecular Medicine</topic><topic>Oncology</topic><topic>Tumor Cells, Cultured</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MacNeil, A</creatorcontrib><creatorcontrib>Sumba, O P</creatorcontrib><creatorcontrib>Lutzke, M L</creatorcontrib><creatorcontrib>Moormann, A</creatorcontrib><creatorcontrib>Rochford, R</creatorcontrib><collection>Springer Nature OA/Free Journals</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MacNeil, A</au><au>Sumba, O P</au><au>Lutzke, M L</au><au>Moormann, A</au><au>Rochford, R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Activation of the Epstein–Barr virus lytic cycle by the latex of the plant Euphorbia tirucalli</atitle><jtitle>British journal of cancer</jtitle><stitle>Br J Cancer</stitle><addtitle>Br J Cancer</addtitle><date>2003-05-19</date><risdate>2003</risdate><volume>88</volume><issue>10</issue><spage>1566</spage><epage>1569</epage><pages>1566-1569</pages><issn>0007-0920</issn><eissn>1532-1827</eissn><coden>BJCAAI</coden><abstract>Exposure to the plant
Euphorbia tirucalli
has been proposed to be a cofactor in the genesis of endemic Burkitt's lymphoma (eBL). The purpose of this study was to examine the effects of unpurified
E. tirucalli
latex on Epstein–Barr virus (EBV) gene expression. A Burkitt lymphoma cell line was treated with varying dilutions of the latex and the effects on EBV gene expression were measured. We observed that the latex was capable of reactivating the EBV lytic cycle in a dose-dependent manner and at dilutions as low as 10
−6
. Simultaneous treatment of cells with
E. tirucalli
latex and the protein kinase C inhibitor 1-(5-isoquinolinesulphonyl)-2-methylpiperazine dihydrochloride blocked lytic cycle activation. These data suggest that environmental exposure to the latex of
E. tirucalli
could directly activate the EBV lytic cycle and provide further evidence of a role for
E. tirucalli
in the aetiology of eBL.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>12771923</pmid><doi>10.1038/sj.bjc.6600929</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Springer Online Journals Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Nature Journals Online; PubMed Central |
| subjects | Biological and medical sciences Biomedical and Life Sciences Biomedicine Burkitt Lymphoma - physiopathology Burkitt Lymphoma - virology Cancer Research Drug Resistance Environmental Exposure Epidemiology Epstein-Barr virus Euphorbia - virology Gene expression Gene Expression Regulation Hematologic and hematopoietic diseases Herpesvirus 4, Human - pathogenicity Humans Kinases Latex - chemistry Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphoma Malaria Medical research Medical sciences Molecular and Cellular Pathology Molecular Medicine Oncology Tumor Cells, Cultured |
| title | Activation of the Epstein–Barr virus lytic cycle by the latex of the plant Euphorbia tirucalli |
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