BAG-1 expression and function in human cancer
BAG-1 is a multifunctional protein that interacts with a wide range of target molecules to regulate apoptosis, proliferation, transcription, metastasis and motility. Interaction with chaperone molecules may mediate many of the effects of BAG-1. The pathways regulated by BAG-1 play key roles in the d...
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| Veröffentlicht in: | British journal of cancer 2002-10, Vol.87 (8), p.834-839 |
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| container_title | British journal of cancer |
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| creator | CUTRESS, R. I TOWNSEND, P. A BRIMMELL, M BATEMAN, A. C HAGUE, A PACKHAM, G |
| description | BAG-1 is a multifunctional protein that interacts with a wide range of target molecules to regulate apoptosis, proliferation, transcription, metastasis and motility. Interaction with chaperone molecules may mediate many of the effects of BAG-1. The pathways regulated by BAG-1 play key roles in the development and progression of cancer and determining response to therapy, and there has been considerable interest in determining the clinical significance of BAG-1 expression in malignant cells. There is an emerging picture that BAG-1 expression is frequently altered in a range of human cancers relative to normal cells and a recent report suggests the exciting possibility that BAG-1 expression may have clinical utility as a prognostic marker in early breast cancer. However, other studies of BAG-1 expression in breast cancer and other cancer types have yielded differing results. It is important to view these findings in the context of current knowledge of BAG-1 expression and function. This review summarises recent progress in understanding the clinical significance of BAG-1 expression in cancer in light of our understanding of BAG-1 function. |
| doi_str_mv | 10.1038/sj.bjc.6600538 |
| format | Article |
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I ; TOWNSEND, P. A ; BRIMMELL, M ; BATEMAN, A. C ; HAGUE, A ; PACKHAM, G</creator><creatorcontrib>CUTRESS, R. I ; TOWNSEND, P. A ; BRIMMELL, M ; BATEMAN, A. C ; HAGUE, A ; PACKHAM, G</creatorcontrib><description>BAG-1 is a multifunctional protein that interacts with a wide range of target molecules to regulate apoptosis, proliferation, transcription, metastasis and motility. Interaction with chaperone molecules may mediate many of the effects of BAG-1. The pathways regulated by BAG-1 play key roles in the development and progression of cancer and determining response to therapy, and there has been considerable interest in determining the clinical significance of BAG-1 expression in malignant cells. There is an emerging picture that BAG-1 expression is frequently altered in a range of human cancers relative to normal cells and a recent report suggests the exciting possibility that BAG-1 expression may have clinical utility as a prognostic marker in early breast cancer. However, other studies of BAG-1 expression in breast cancer and other cancer types have yielded differing results. It is important to view these findings in the context of current knowledge of BAG-1 expression and function. This review summarises recent progress in understanding the clinical significance of BAG-1 expression in cancer in light of our understanding of BAG-1 function.</description><identifier>ISSN: 0007-0920</identifier><identifier>EISSN: 1532-1827</identifier><identifier>DOI: 10.1038/sj.bjc.6600538</identifier><identifier>PMID: 12373595</identifier><identifier>CODEN: BJCAAI</identifier><language>eng</language><publisher>Basingstoke: Nature Publishing Group</publisher><subject>Apoptosis ; Biological and medical sciences ; Biomarkers, Tumor - analysis ; Breast cancer ; Cancer research ; Carrier Proteins - metabolism ; Cell Adhesion - physiology ; Cell Division ; Clinical significance ; Clinical Trials as Topic ; Cytoplasm ; DNA-Binding Proteins ; Growth factors ; Humans ; Kinases ; Localization ; Medical research ; Medical sciences ; Metastasis ; Minireview ; Multiple tumors. Solid tumors. Tumors in childhood (general aspects) ; Neoplasm Metastasis ; Neoplasms - genetics ; Neoplasms - metabolism ; Neoplasms - pathology ; Peptides ; Prognosis ; Proteins ; Transcription Factors ; Transcription, Genetic - physiology ; Tumors</subject><ispartof>British journal of cancer, 2002-10, Vol.87 (8), p.834-839</ispartof><rights>2003 INIST-CNRS</rights><rights>Copyright 2002 Cancer Research UK</rights><rights>Copyright Nature Publishing Group Oct 7, 2002</rights><rights>Copyright © 2002 Cancer Research UK 2002 Cancer Research UK</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3808-ccbb27cea9bc9becc4e1f21e32f9d6adb63fe7718c6cfa26780c7c10378d9b793</citedby><cites>FETCH-LOGICAL-c3808-ccbb27cea9bc9becc4e1f21e32f9d6adb63fe7718c6cfa26780c7c10378d9b793</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2376178/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2376178/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,2727,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14353752$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12373595$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>CUTRESS, R. I</creatorcontrib><creatorcontrib>TOWNSEND, P. A</creatorcontrib><creatorcontrib>BRIMMELL, M</creatorcontrib><creatorcontrib>BATEMAN, A. C</creatorcontrib><creatorcontrib>HAGUE, A</creatorcontrib><creatorcontrib>PACKHAM, G</creatorcontrib><title>BAG-1 expression and function in human cancer</title><title>British journal of cancer</title><addtitle>Br J Cancer</addtitle><description>BAG-1 is a multifunctional protein that interacts with a wide range of target molecules to regulate apoptosis, proliferation, transcription, metastasis and motility. Interaction with chaperone molecules may mediate many of the effects of BAG-1. The pathways regulated by BAG-1 play key roles in the development and progression of cancer and determining response to therapy, and there has been considerable interest in determining the clinical significance of BAG-1 expression in malignant cells. There is an emerging picture that BAG-1 expression is frequently altered in a range of human cancers relative to normal cells and a recent report suggests the exciting possibility that BAG-1 expression may have clinical utility as a prognostic marker in early breast cancer. However, other studies of BAG-1 expression in breast cancer and other cancer types have yielded differing results. It is important to view these findings in the context of current knowledge of BAG-1 expression and function. This review summarises recent progress in understanding the clinical significance of BAG-1 expression in cancer in light of our understanding of BAG-1 function.</description><subject>Apoptosis</subject><subject>Biological and medical sciences</subject><subject>Biomarkers, Tumor - analysis</subject><subject>Breast cancer</subject><subject>Cancer research</subject><subject>Carrier Proteins - metabolism</subject><subject>Cell Adhesion - physiology</subject><subject>Cell Division</subject><subject>Clinical significance</subject><subject>Clinical Trials as Topic</subject><subject>Cytoplasm</subject><subject>DNA-Binding Proteins</subject><subject>Growth factors</subject><subject>Humans</subject><subject>Kinases</subject><subject>Localization</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Metastasis</subject><subject>Minireview</subject><subject>Multiple tumors. Solid tumors. Tumors in childhood (general aspects)</subject><subject>Neoplasm Metastasis</subject><subject>Neoplasms - genetics</subject><subject>Neoplasms - metabolism</subject><subject>Neoplasms - pathology</subject><subject>Peptides</subject><subject>Prognosis</subject><subject>Proteins</subject><subject>Transcription Factors</subject><subject>Transcription, Genetic - physiology</subject><subject>Tumors</subject><issn>0007-0920</issn><issn>1532-1827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpdkUlPwzAQhS0EglK4cgNFSHBL8dJ4uSCVik2qxAXOljNxIFHqFLtB8O9x1dACJ2vkb97Mm4fQCcEjgpm8CvUor2HEOcYZkztoQDJGUyKp2EUDjLFIsaL4AB2GUMdSYSn20QGhTLBMZQOU3kzuU5LYz4W3IVStS4wrkrJzsFwVlUveurlxCRgH1h-hvdI0wR737xC93N0-Tx_S2dP943QyS4FJLFOAPKcCrFE5qNwCjC0pKbGMlqrgpsg5K60QRAKH0lAuJAYB0Y-QhcqFYkN0vdZddPncFmDd0ptGL3w1N_5Lt6bSf39c9aZf2w8dfXEiZBS47AV8-97ZsNTzKoBtGuNs2wUtKOF8rGgEz_-Bddt5F81pSpUSY8ZW0GgNgW9D8LbcbEKwXsWgQ61jDLqPITac_d5_i_d3j8BFD5gApil9PG8VttyYZUxkq8mna86ZZeftBvgZ9A2CTppw</recordid><startdate>20021007</startdate><enddate>20021007</enddate><creator>CUTRESS, R. 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I</au><au>TOWNSEND, P. A</au><au>BRIMMELL, M</au><au>BATEMAN, A. C</au><au>HAGUE, A</au><au>PACKHAM, G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>BAG-1 expression and function in human cancer</atitle><jtitle>British journal of cancer</jtitle><addtitle>Br J Cancer</addtitle><date>2002-10-07</date><risdate>2002</risdate><volume>87</volume><issue>8</issue><spage>834</spage><epage>839</epage><pages>834-839</pages><issn>0007-0920</issn><eissn>1532-1827</eissn><coden>BJCAAI</coden><abstract>BAG-1 is a multifunctional protein that interacts with a wide range of target molecules to regulate apoptosis, proliferation, transcription, metastasis and motility. Interaction with chaperone molecules may mediate many of the effects of BAG-1. The pathways regulated by BAG-1 play key roles in the development and progression of cancer and determining response to therapy, and there has been considerable interest in determining the clinical significance of BAG-1 expression in malignant cells. There is an emerging picture that BAG-1 expression is frequently altered in a range of human cancers relative to normal cells and a recent report suggests the exciting possibility that BAG-1 expression may have clinical utility as a prognostic marker in early breast cancer. However, other studies of BAG-1 expression in breast cancer and other cancer types have yielded differing results. It is important to view these findings in the context of current knowledge of BAG-1 expression and function. This review summarises recent progress in understanding the clinical significance of BAG-1 expression in cancer in light of our understanding of BAG-1 function.</abstract><cop>Basingstoke</cop><pub>Nature Publishing Group</pub><pmid>12373595</pmid><doi>10.1038/sj.bjc.6600538</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Apoptosis Biological and medical sciences Biomarkers, Tumor - analysis Breast cancer Cancer research Carrier Proteins - metabolism Cell Adhesion - physiology Cell Division Clinical significance Clinical Trials as Topic Cytoplasm DNA-Binding Proteins Growth factors Humans Kinases Localization Medical research Medical sciences Metastasis Minireview Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Neoplasm Metastasis Neoplasms - genetics Neoplasms - metabolism Neoplasms - pathology Peptides Prognosis Proteins Transcription Factors Transcription, Genetic - physiology Tumors |
| title | BAG-1 expression and function in human cancer |
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