Laminin-1-induced migration of multiple myeloma cells involves the high-affinity 67 kD laminin receptor
The 67 kD laminin receptor (67LR) binds laminin-1 (LN), major component of the basement membrane, with high affinity. In this study, we demonstrated that human multiple myeloma cell lines (HMCL) and murine 5T2MM cells express 67LR. CD38 bright+ plasma cells in fresh multiple myeloma (MM) bone marrow...
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| Veröffentlicht in: | British journal of cancer 2001-11, Vol.85 (9), p.1387-1395 |
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| creator | Vande Broek, I Vanderkerken, K De Greef, C Asosingh, K Straetmans, N Van Camp, B Van Riet, I |
| description | The 67 kD laminin receptor (67LR) binds laminin-1 (LN), major component of the basement membrane, with high affinity. In this study, we demonstrated that human multiple myeloma cell lines (HMCL) and murine 5T2MM cells express 67LR. CD38
bright+
plasma cells in fresh multiple myeloma (MM) bone marrow (BM) samples showed weaker 67LR expression, but expression increased after direct exposure to a BM endothelial cell line (4LHBMEC). LN stimulated the in vitro migration of 3 HMCL (MM5.1, U266 and MMS.1), primary MM cells and the murine 5T2MM cells. 67LR has been shown to mediate the actions of LN through binding to CDPGYIGSR, a 9 amino acid sequence from the B1 chain of LN. MM cell migration was partially blocked by peptide 11, a synthetic nonapeptide derived from this amino sequence and also by a blocking antiserum against 67LR. Co-injection of peptide 11 with 5T2MM cells in a murine in vivo model of MM resulted in a decreased homing of 5T2MM cells to the BM compartment. In conclusion, LN acts as a chemoattractant for MM cells by interaction with 67LR. This interaction might be important during extravasation of circulating MM cells. © 2001 Cancer Research Campaign
http://www.bjcancer.com |
| doi_str_mv | 10.1054/bjoc.2001.2078 |
| format | Article |
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bright+
plasma cells in fresh multiple myeloma (MM) bone marrow (BM) samples showed weaker 67LR expression, but expression increased after direct exposure to a BM endothelial cell line (4LHBMEC). LN stimulated the in vitro migration of 3 HMCL (MM5.1, U266 and MMS.1), primary MM cells and the murine 5T2MM cells. 67LR has been shown to mediate the actions of LN through binding to CDPGYIGSR, a 9 amino acid sequence from the B1 chain of LN. MM cell migration was partially blocked by peptide 11, a synthetic nonapeptide derived from this amino sequence and also by a blocking antiserum against 67LR. Co-injection of peptide 11 with 5T2MM cells in a murine in vivo model of MM resulted in a decreased homing of 5T2MM cells to the BM compartment. In conclusion, LN acts as a chemoattractant for MM cells by interaction with 67LR. This interaction might be important during extravasation of circulating MM cells. © 2001 Cancer Research Campaign
http://www.bjcancer.com</description><identifier>ISSN: 0007-0920</identifier><identifier>EISSN: 1532-1827</identifier><identifier>DOI: 10.1054/bjoc.2001.2078</identifier><identifier>PMID: 11720479</identifier><identifier>CODEN: BJCAAI</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Animals ; Antigens ; Biological and medical sciences ; Biomedical and Life Sciences ; Biomedicine ; Bone marrow ; Bone Marrow Cells ; Cancer Research ; Cell adhesion & migration ; Cell Movement ; Chemotactic Factors ; Cloning ; Drug Resistance ; Epidemiology ; Gene Expression Regulation, Neoplastic ; Hematologic and hematopoietic diseases ; Hematology ; Humans ; Laminin - pharmacology ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Magnetic fields ; Medical research ; Medical sciences ; Metastasis ; Mice ; Molecular Medicine ; Multiple myeloma ; Multiple Myeloma - pathology ; Neoplastic Cells, Circulating ; Oncology ; Peptides ; Proteins ; Receptors, Laminin - physiology ; Regular ; regular-article ; Tumor Cells, Cultured</subject><ispartof>British journal of cancer, 2001-11, Vol.85 (9), p.1387-1395</ispartof><rights>The Author(s) 2001</rights><rights>2002 INIST-CNRS</rights><rights>Copyright 2001 Cancer Research Campaign</rights><rights>Copyright Nature Publishing Group Nov 2001</rights><rights>Copyright © 2001 Cancer Research Campaign 2001 Cancer Research Campaign</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c603t-7a8fbb01b098006f1d2da05bf4d0e50c377504c601ea1dca92cb28408c9e8e9e3</citedby><cites>FETCH-LOGICAL-c603t-7a8fbb01b098006f1d2da05bf4d0e50c377504c601ea1dca92cb28408c9e8e9e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2375239/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2375239/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,2727,27924,27925,41488,42557,51319,53791,53793</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14130628$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11720479$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vande Broek, I</creatorcontrib><creatorcontrib>Vanderkerken, K</creatorcontrib><creatorcontrib>De Greef, C</creatorcontrib><creatorcontrib>Asosingh, K</creatorcontrib><creatorcontrib>Straetmans, N</creatorcontrib><creatorcontrib>Van Camp, B</creatorcontrib><creatorcontrib>Van Riet, I</creatorcontrib><title>Laminin-1-induced migration of multiple myeloma cells involves the high-affinity 67 kD laminin receptor</title><title>British journal of cancer</title><addtitle>Br J Cancer</addtitle><addtitle>Br J Cancer</addtitle><description>The 67 kD laminin receptor (67LR) binds laminin-1 (LN), major component of the basement membrane, with high affinity. In this study, we demonstrated that human multiple myeloma cell lines (HMCL) and murine 5T2MM cells express 67LR. CD38
bright+
plasma cells in fresh multiple myeloma (MM) bone marrow (BM) samples showed weaker 67LR expression, but expression increased after direct exposure to a BM endothelial cell line (4LHBMEC). LN stimulated the in vitro migration of 3 HMCL (MM5.1, U266 and MMS.1), primary MM cells and the murine 5T2MM cells. 67LR has been shown to mediate the actions of LN through binding to CDPGYIGSR, a 9 amino acid sequence from the B1 chain of LN. MM cell migration was partially blocked by peptide 11, a synthetic nonapeptide derived from this amino sequence and also by a blocking antiserum against 67LR. Co-injection of peptide 11 with 5T2MM cells in a murine in vivo model of MM resulted in a decreased homing of 5T2MM cells to the BM compartment. In conclusion, LN acts as a chemoattractant for MM cells by interaction with 67LR. This interaction might be important during extravasation of circulating MM cells. © 2001 Cancer Research Campaign
http://www.bjcancer.com</description><subject>Animals</subject><subject>Antigens</subject><subject>Biological and medical sciences</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Bone marrow</subject><subject>Bone Marrow Cells</subject><subject>Cancer Research</subject><subject>Cell adhesion & migration</subject><subject>Cell Movement</subject><subject>Chemotactic Factors</subject><subject>Cloning</subject><subject>Drug Resistance</subject><subject>Epidemiology</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Hematology</subject><subject>Humans</subject><subject>Laminin - pharmacology</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Magnetic fields</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Metastasis</subject><subject>Mice</subject><subject>Molecular Medicine</subject><subject>Multiple myeloma</subject><subject>Multiple Myeloma - pathology</subject><subject>Neoplastic Cells, Circulating</subject><subject>Oncology</subject><subject>Peptides</subject><subject>Proteins</subject><subject>Receptors, Laminin - physiology</subject><subject>Regular</subject><subject>regular-article</subject><subject>Tumor Cells, Cultured</subject><issn>0007-0920</issn><issn>1532-1827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kU2r1DAUhoMo3vHq1p0SBHXVuSfpR5qNINdPGHCj65CmpzMZ22RM2oH596Z2uKOCbhLCec6TnLyEPGWwZlAWN83emzUHYGkR9T2yYmXOM1ZzcZ-sAEBkIDlckUcx7tNRQi0ekivGBIdCyBXZbvRgnXUZy6xrJ4MtHew26NF6R31Hh6kf7aFHOpyw94OmBvs-UuuOvj9ipOMO6c5ud5nuuuQZT7QS9Ps72i9aGtDgYfThMXnQ6T7ik_N-Tb59eP_19lO2-fLx8-3bTWYqyMdM6LprGmANyBqg6ljLWw1l0xUtYAkmF6KEIrEMNWuNltw0vC6gNhJrlJhfkzeL9zA1A7YG3Rh0rw7BDjqclNdW_Vlxdqe2_qh4LkqeyyR4fRYE_2PCOKrBxnlo7dBPUYmKc8GZZIl89X-Sc1lXAhL44i9w76fg0jekW1MoeV7OtvUCmeBjDNjdvZmBmqNWc9RqjlrNUaeG579PesHP2Sbg5RnQ0ei-C9oZGy9cwXKo-Cy6WbiYSm6L4fK8f179bOlwepwC3imrSv6q_wRVacv5</recordid><startdate>20011102</startdate><enddate>20011102</enddate><creator>Vande Broek, I</creator><creator>Vanderkerken, K</creator><creator>De Greef, C</creator><creator>Asosingh, K</creator><creator>Straetmans, N</creator><creator>Van Camp, B</creator><creator>Van Riet, I</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>7T5</scope><scope>5PM</scope></search><sort><creationdate>20011102</creationdate><title>Laminin-1-induced migration of multiple myeloma cells involves the high-affinity 67 kD laminin receptor</title><author>Vande Broek, I ; Vanderkerken, K ; De Greef, C ; Asosingh, K ; Straetmans, N ; Van Camp, B ; Van Riet, I</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c603t-7a8fbb01b098006f1d2da05bf4d0e50c377504c601ea1dca92cb28408c9e8e9e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Animals</topic><topic>Antigens</topic><topic>Biological and medical sciences</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Bone marrow</topic><topic>Bone Marrow Cells</topic><topic>Cancer Research</topic><topic>Cell adhesion & migration</topic><topic>Cell Movement</topic><topic>Chemotactic Factors</topic><topic>Cloning</topic><topic>Drug Resistance</topic><topic>Epidemiology</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Hematology</topic><topic>Humans</topic><topic>Laminin - pharmacology</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Magnetic fields</topic><topic>Medical research</topic><topic>Medical sciences</topic><topic>Metastasis</topic><topic>Mice</topic><topic>Molecular Medicine</topic><topic>Multiple myeloma</topic><topic>Multiple Myeloma - pathology</topic><topic>Neoplastic Cells, Circulating</topic><topic>Oncology</topic><topic>Peptides</topic><topic>Proteins</topic><topic>Receptors, Laminin - physiology</topic><topic>Regular</topic><topic>regular-article</topic><topic>Tumor Cells, Cultured</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vande Broek, I</creatorcontrib><creatorcontrib>Vanderkerken, K</creatorcontrib><creatorcontrib>De Greef, C</creatorcontrib><creatorcontrib>Asosingh, K</creatorcontrib><creatorcontrib>Straetmans, N</creatorcontrib><creatorcontrib>Van Camp, B</creatorcontrib><creatorcontrib>Van Riet, I</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vande Broek, I</au><au>Vanderkerken, K</au><au>De Greef, C</au><au>Asosingh, K</au><au>Straetmans, N</au><au>Van Camp, B</au><au>Van Riet, I</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Laminin-1-induced migration of multiple myeloma cells involves the high-affinity 67 kD laminin receptor</atitle><jtitle>British journal of cancer</jtitle><stitle>Br J Cancer</stitle><addtitle>Br J Cancer</addtitle><date>2001-11-02</date><risdate>2001</risdate><volume>85</volume><issue>9</issue><spage>1387</spage><epage>1395</epage><pages>1387-1395</pages><issn>0007-0920</issn><eissn>1532-1827</eissn><coden>BJCAAI</coden><abstract>The 67 kD laminin receptor (67LR) binds laminin-1 (LN), major component of the basement membrane, with high affinity. In this study, we demonstrated that human multiple myeloma cell lines (HMCL) and murine 5T2MM cells express 67LR. CD38
bright+
plasma cells in fresh multiple myeloma (MM) bone marrow (BM) samples showed weaker 67LR expression, but expression increased after direct exposure to a BM endothelial cell line (4LHBMEC). LN stimulated the in vitro migration of 3 HMCL (MM5.1, U266 and MMS.1), primary MM cells and the murine 5T2MM cells. 67LR has been shown to mediate the actions of LN through binding to CDPGYIGSR, a 9 amino acid sequence from the B1 chain of LN. MM cell migration was partially blocked by peptide 11, a synthetic nonapeptide derived from this amino sequence and also by a blocking antiserum against 67LR. Co-injection of peptide 11 with 5T2MM cells in a murine in vivo model of MM resulted in a decreased homing of 5T2MM cells to the BM compartment. In conclusion, LN acts as a chemoattractant for MM cells by interaction with 67LR. This interaction might be important during extravasation of circulating MM cells. © 2001 Cancer Research Campaign
http://www.bjcancer.com</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>11720479</pmid><doi>10.1054/bjoc.2001.2078</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Antigens Biological and medical sciences Biomedical and Life Sciences Biomedicine Bone marrow Bone Marrow Cells Cancer Research Cell adhesion & migration Cell Movement Chemotactic Factors Cloning Drug Resistance Epidemiology Gene Expression Regulation, Neoplastic Hematologic and hematopoietic diseases Hematology Humans Laminin - pharmacology Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Magnetic fields Medical research Medical sciences Metastasis Mice Molecular Medicine Multiple myeloma Multiple Myeloma - pathology Neoplastic Cells, Circulating Oncology Peptides Proteins Receptors, Laminin - physiology Regular regular-article Tumor Cells, Cultured |
| title | Laminin-1-induced migration of multiple myeloma cells involves the high-affinity 67 kD laminin receptor |
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