Nucleolar damage correlates with neurotoxicity induced by different platinum drugs
Platinum-based drugs are very useful in cancer therapy but are associated with neurotoxicity in the clinic. To investigate the mechanism of neurotoxicity, dorsal root ganglia of rats treated with various platinum drugs were studied. Cell body, nuclear and nucleolar dimensions of dorsal root ganglia...
Gespeichert in:
| Veröffentlicht in: | British journal of cancer 2001-10, Vol.85 (8), p.1219-1225 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1225 |
|---|---|
| container_issue | 8 |
| container_start_page | 1219 |
| container_title | British journal of cancer |
| container_volume | 85 |
| creator | McKeage, M J Hsu, T Screnci, D Haddad, G Baguley, B C |
| description | Platinum-based drugs are very useful in cancer therapy but are associated with neurotoxicity in the clinic. To investigate the mechanism of neurotoxicity, dorsal root ganglia of rats treated with various platinum drugs were studied. Cell body, nuclear and nucleolar dimensions of dorsal root ganglia sensory nerve cells were measured to determine morphological toxicity. Sensory nerve conduction velocity was measured to determine functional toxicity. After a single dose of oxaliplatin (10 mg kg
–1
), no significant change in nuclear and cell body diameter was seen but decreased nucleolar size was apparent within a few hours of treatment. Changes in nucleolar size were maximal at 24 hours, recovered very slowly and showed a non-linear dependence on oxaliplatin dose (r
2
= 0.99). Functional toxicity was delayed in onset until 14 days after a single dose of oxaliplatin but eventually recovered 3 months after treatment. Multiple doses of cisplatin, carboplatin, oxaliplatin,
R
,
R
-ormaplatin and
S
,
S
-ormaplatin were also associated with time-dependent reduction in nucleolar size. A linear correlation was obtained between the rate of change in nucleolar size during multiple dose treatment with the series of platinum drugs and the time taken for the development of altered sensory nerve conduction velocity (r
2
= 0.86;
P
< 0.024). Damage to the nucleolus of ganglionic sensory neurons is therefore linked to the neurotoxicity of platinum-based drugs, possibly through mechanisms resulting in the inhibition of rRNA synthesis. © 2001 Cancer Research Campaign
http://www.bjcancer.com |
| doi_str_mv | 10.1054/bjoc.2001.2024 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2375155</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>954574856</sourcerecordid><originalsourceid>FETCH-LOGICAL-c537t-c46ab6a3ba055cee217439089a8e5c7218c0c672842f887af3d764603e4aac133</originalsourceid><addsrcrecordid>eNp1kUuLFDEUhYMoTtu6dacUgriqnjwqj9oMyOALBgXRdUilbvWkqUrapKL2vzdlN9MquEkI97sn596D0FOCNwTz5rLbBbuhGJNy0OYeWhHOaE0UlffRCmMsa9xSfIEepbQrzxYr-RBdECIJVkyt0OeP2Y4QRhOr3kxmC5UNMcJoZkjVDzffVh5yDHP46aybD5XzfbbQV92h6t0wQAQ_V_uCO5-nqo95mx6jB4MZEzw53Wv09e2bL9fv65tP7z5cv76pLWdyrm0jTCcM6wzm3AJQIhtW_LVGAbeSEmWxFZKqhg5KSTOwXopGYAaNMZYwtkZXR9197ibobXESzaj30U0mHnQwTv9d8e5Wb8N3TZnkhPMi8OokEMO3DGnWk0sWxtF4CDnpljdcNoqLQr74h9yFHH2ZTlPatoKJss012hwhG0NKEYY7KwTrJSy9hKWXsPQSVml4_ucAZ_yUTgFengCTrBmHaLx16cw1ZQu0XYQuj1wqJb-FeLb336-fHTu8mXOEO0kh2t_1XwsZt5g</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>229963608</pqid></control><display><type>article</type><title>Nucleolar damage correlates with neurotoxicity induced by different platinum drugs</title><source>MEDLINE</source><source>Nature</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>SpringerLink Journals - AutoHoldings</source><creator>McKeage, M J ; Hsu, T ; Screnci, D ; Haddad, G ; Baguley, B C</creator><creatorcontrib>McKeage, M J ; Hsu, T ; Screnci, D ; Haddad, G ; Baguley, B C</creatorcontrib><description>Platinum-based drugs are very useful in cancer therapy but are associated with neurotoxicity in the clinic. To investigate the mechanism of neurotoxicity, dorsal root ganglia of rats treated with various platinum drugs were studied. Cell body, nuclear and nucleolar dimensions of dorsal root ganglia sensory nerve cells were measured to determine morphological toxicity. Sensory nerve conduction velocity was measured to determine functional toxicity. After a single dose of oxaliplatin (10 mg kg
–1
), no significant change in nuclear and cell body diameter was seen but decreased nucleolar size was apparent within a few hours of treatment. Changes in nucleolar size were maximal at 24 hours, recovered very slowly and showed a non-linear dependence on oxaliplatin dose (r
2
= 0.99). Functional toxicity was delayed in onset until 14 days after a single dose of oxaliplatin but eventually recovered 3 months after treatment. Multiple doses of cisplatin, carboplatin, oxaliplatin,
R
,
R
-ormaplatin and
S
,
S
-ormaplatin were also associated with time-dependent reduction in nucleolar size. A linear correlation was obtained between the rate of change in nucleolar size during multiple dose treatment with the series of platinum drugs and the time taken for the development of altered sensory nerve conduction velocity (r
2
= 0.86;
P
< 0.024). Damage to the nucleolus of ganglionic sensory neurons is therefore linked to the neurotoxicity of platinum-based drugs, possibly through mechanisms resulting in the inhibition of rRNA synthesis. © 2001 Cancer Research Campaign
http://www.bjcancer.com</description><identifier>ISSN: 0007-0920</identifier><identifier>EISSN: 1532-1827</identifier><identifier>DOI: 10.1054/bjoc.2001.2024</identifier><identifier>PMID: 11710838</identifier><identifier>CODEN: BJCAAI</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Animals ; Antineoplastic Agents - toxicity ; Biological and medical sciences ; Biomedical and Life Sciences ; Biomedicine ; Cancer Research ; Cancer therapies ; Carboplatin - toxicity ; Cell cycle ; Cell Nucleolus - drug effects ; Chemotherapy ; Cisplatin - toxicity ; DNA Adducts - analysis ; DNA damage ; Dose-Response Relationship, Drug ; Drug dosages ; Drug Resistance ; Drug toxicity and drugs side effects treatment ; Epidemiology ; Female ; Ganglia, Spinal - drug effects ; Ganglia, Spinal - pathology ; Ganglia, Spinal - physiology ; Health sciences ; Medical research ; Medical sciences ; Molecular Medicine ; Morphology ; Neural Conduction - drug effects ; Neurotoxicity ; Oncology ; Organoplatinum Compounds - toxicity ; Pharmacology. Drug treatments ; Rats ; Rats, Wistar ; Regular ; regular-article ; Toxicity ; Toxicity: nervous system and muscle</subject><ispartof>British journal of cancer, 2001-10, Vol.85 (8), p.1219-1225</ispartof><rights>The Author(s) 2001</rights><rights>2002 INIST-CNRS</rights><rights>Copyright 2001 Cancer Research Campaign http://www.bjcancer.com.</rights><rights>Copyright Nature Publishing Group Oct 2001</rights><rights>Copyright © 2001 Cancer Research Campaign 2001 Cancer Research Campaign</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c537t-c46ab6a3ba055cee217439089a8e5c7218c0c672842f887af3d764603e4aac133</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2375155/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2375155/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,2727,27924,27925,41488,42557,51319,53791,53793</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14133294$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11710838$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>McKeage, M J</creatorcontrib><creatorcontrib>Hsu, T</creatorcontrib><creatorcontrib>Screnci, D</creatorcontrib><creatorcontrib>Haddad, G</creatorcontrib><creatorcontrib>Baguley, B C</creatorcontrib><title>Nucleolar damage correlates with neurotoxicity induced by different platinum drugs</title><title>British journal of cancer</title><addtitle>Br J Cancer</addtitle><addtitle>Br J Cancer</addtitle><description>Platinum-based drugs are very useful in cancer therapy but are associated with neurotoxicity in the clinic. To investigate the mechanism of neurotoxicity, dorsal root ganglia of rats treated with various platinum drugs were studied. Cell body, nuclear and nucleolar dimensions of dorsal root ganglia sensory nerve cells were measured to determine morphological toxicity. Sensory nerve conduction velocity was measured to determine functional toxicity. After a single dose of oxaliplatin (10 mg kg
–1
), no significant change in nuclear and cell body diameter was seen but decreased nucleolar size was apparent within a few hours of treatment. Changes in nucleolar size were maximal at 24 hours, recovered very slowly and showed a non-linear dependence on oxaliplatin dose (r
2
= 0.99). Functional toxicity was delayed in onset until 14 days after a single dose of oxaliplatin but eventually recovered 3 months after treatment. Multiple doses of cisplatin, carboplatin, oxaliplatin,
R
,
R
-ormaplatin and
S
,
S
-ormaplatin were also associated with time-dependent reduction in nucleolar size. A linear correlation was obtained between the rate of change in nucleolar size during multiple dose treatment with the series of platinum drugs and the time taken for the development of altered sensory nerve conduction velocity (r
2
= 0.86;
P
< 0.024). Damage to the nucleolus of ganglionic sensory neurons is therefore linked to the neurotoxicity of platinum-based drugs, possibly through mechanisms resulting in the inhibition of rRNA synthesis. © 2001 Cancer Research Campaign
http://www.bjcancer.com</description><subject>Animals</subject><subject>Antineoplastic Agents - toxicity</subject><subject>Biological and medical sciences</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer Research</subject><subject>Cancer therapies</subject><subject>Carboplatin - toxicity</subject><subject>Cell cycle</subject><subject>Cell Nucleolus - drug effects</subject><subject>Chemotherapy</subject><subject>Cisplatin - toxicity</subject><subject>DNA Adducts - analysis</subject><subject>DNA damage</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drug dosages</subject><subject>Drug Resistance</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Ganglia, Spinal - drug effects</subject><subject>Ganglia, Spinal - pathology</subject><subject>Ganglia, Spinal - physiology</subject><subject>Health sciences</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Molecular Medicine</subject><subject>Morphology</subject><subject>Neural Conduction - drug effects</subject><subject>Neurotoxicity</subject><subject>Oncology</subject><subject>Organoplatinum Compounds - toxicity</subject><subject>Pharmacology. Drug treatments</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Regular</subject><subject>regular-article</subject><subject>Toxicity</subject><subject>Toxicity: nervous system and muscle</subject><issn>0007-0920</issn><issn>1532-1827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kUuLFDEUhYMoTtu6dacUgriqnjwqj9oMyOALBgXRdUilbvWkqUrapKL2vzdlN9MquEkI97sn596D0FOCNwTz5rLbBbuhGJNy0OYeWhHOaE0UlffRCmMsa9xSfIEepbQrzxYr-RBdECIJVkyt0OeP2Y4QRhOr3kxmC5UNMcJoZkjVDzffVh5yDHP46aybD5XzfbbQV92h6t0wQAQ_V_uCO5-nqo95mx6jB4MZEzw53Wv09e2bL9fv65tP7z5cv76pLWdyrm0jTCcM6wzm3AJQIhtW_LVGAbeSEmWxFZKqhg5KSTOwXopGYAaNMZYwtkZXR9197ibobXESzaj30U0mHnQwTv9d8e5Wb8N3TZnkhPMi8OokEMO3DGnWk0sWxtF4CDnpljdcNoqLQr74h9yFHH2ZTlPatoKJss012hwhG0NKEYY7KwTrJSy9hKWXsPQSVml4_ucAZ_yUTgFengCTrBmHaLx16cw1ZQu0XYQuj1wqJb-FeLb336-fHTu8mXOEO0kh2t_1XwsZt5g</recordid><startdate>20011019</startdate><enddate>20011019</enddate><creator>McKeage, M J</creator><creator>Hsu, T</creator><creator>Screnci, D</creator><creator>Haddad, G</creator><creator>Baguley, B C</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7TK</scope><scope>5PM</scope></search><sort><creationdate>20011019</creationdate><title>Nucleolar damage correlates with neurotoxicity induced by different platinum drugs</title><author>McKeage, M J ; Hsu, T ; Screnci, D ; Haddad, G ; Baguley, B C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c537t-c46ab6a3ba055cee217439089a8e5c7218c0c672842f887af3d764603e4aac133</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Animals</topic><topic>Antineoplastic Agents - toxicity</topic><topic>Biological and medical sciences</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cancer Research</topic><topic>Cancer therapies</topic><topic>Carboplatin - toxicity</topic><topic>Cell cycle</topic><topic>Cell Nucleolus - drug effects</topic><topic>Chemotherapy</topic><topic>Cisplatin - toxicity</topic><topic>DNA Adducts - analysis</topic><topic>DNA damage</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drug dosages</topic><topic>Drug Resistance</topic><topic>Drug toxicity and drugs side effects treatment</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Ganglia, Spinal - drug effects</topic><topic>Ganglia, Spinal - pathology</topic><topic>Ganglia, Spinal - physiology</topic><topic>Health sciences</topic><topic>Medical research</topic><topic>Medical sciences</topic><topic>Molecular Medicine</topic><topic>Morphology</topic><topic>Neural Conduction - drug effects</topic><topic>Neurotoxicity</topic><topic>Oncology</topic><topic>Organoplatinum Compounds - toxicity</topic><topic>Pharmacology. Drug treatments</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Regular</topic><topic>regular-article</topic><topic>Toxicity</topic><topic>Toxicity: nervous system and muscle</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>McKeage, M J</creatorcontrib><creatorcontrib>Hsu, T</creatorcontrib><creatorcontrib>Screnci, D</creatorcontrib><creatorcontrib>Haddad, G</creatorcontrib><creatorcontrib>Baguley, B C</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Neurosciences Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>McKeage, M J</au><au>Hsu, T</au><au>Screnci, D</au><au>Haddad, G</au><au>Baguley, B C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nucleolar damage correlates with neurotoxicity induced by different platinum drugs</atitle><jtitle>British journal of cancer</jtitle><stitle>Br J Cancer</stitle><addtitle>Br J Cancer</addtitle><date>2001-10-19</date><risdate>2001</risdate><volume>85</volume><issue>8</issue><spage>1219</spage><epage>1225</epage><pages>1219-1225</pages><issn>0007-0920</issn><eissn>1532-1827</eissn><coden>BJCAAI</coden><abstract>Platinum-based drugs are very useful in cancer therapy but are associated with neurotoxicity in the clinic. To investigate the mechanism of neurotoxicity, dorsal root ganglia of rats treated with various platinum drugs were studied. Cell body, nuclear and nucleolar dimensions of dorsal root ganglia sensory nerve cells were measured to determine morphological toxicity. Sensory nerve conduction velocity was measured to determine functional toxicity. After a single dose of oxaliplatin (10 mg kg
–1
), no significant change in nuclear and cell body diameter was seen but decreased nucleolar size was apparent within a few hours of treatment. Changes in nucleolar size were maximal at 24 hours, recovered very slowly and showed a non-linear dependence on oxaliplatin dose (r
2
= 0.99). Functional toxicity was delayed in onset until 14 days after a single dose of oxaliplatin but eventually recovered 3 months after treatment. Multiple doses of cisplatin, carboplatin, oxaliplatin,
R
,
R
-ormaplatin and
S
,
S
-ormaplatin were also associated with time-dependent reduction in nucleolar size. A linear correlation was obtained between the rate of change in nucleolar size during multiple dose treatment with the series of platinum drugs and the time taken for the development of altered sensory nerve conduction velocity (r
2
= 0.86;
P
< 0.024). Damage to the nucleolus of ganglionic sensory neurons is therefore linked to the neurotoxicity of platinum-based drugs, possibly through mechanisms resulting in the inhibition of rRNA synthesis. © 2001 Cancer Research Campaign
http://www.bjcancer.com</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>11710838</pmid><doi>10.1054/bjoc.2001.2024</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0007-0920 |
| ispartof | British journal of cancer, 2001-10, Vol.85 (8), p.1219-1225 |
| issn | 0007-0920 1532-1827 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2375155 |
| source | MEDLINE; Nature; EZB-FREE-00999 freely available EZB journals; PubMed Central; SpringerLink Journals - AutoHoldings |
| subjects | Animals Antineoplastic Agents - toxicity Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer Research Cancer therapies Carboplatin - toxicity Cell cycle Cell Nucleolus - drug effects Chemotherapy Cisplatin - toxicity DNA Adducts - analysis DNA damage Dose-Response Relationship, Drug Drug dosages Drug Resistance Drug toxicity and drugs side effects treatment Epidemiology Female Ganglia, Spinal - drug effects Ganglia, Spinal - pathology Ganglia, Spinal - physiology Health sciences Medical research Medical sciences Molecular Medicine Morphology Neural Conduction - drug effects Neurotoxicity Oncology Organoplatinum Compounds - toxicity Pharmacology. Drug treatments Rats Rats, Wistar Regular regular-article Toxicity Toxicity: nervous system and muscle |
| title | Nucleolar damage correlates with neurotoxicity induced by different platinum drugs |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T09%3A18%3A05IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Nucleolar%20damage%20correlates%20with%20neurotoxicity%20induced%20by%20different%20platinum%20drugs&rft.jtitle=British%20journal%20of%20cancer&rft.au=McKeage,%20M%20J&rft.date=2001-10-19&rft.volume=85&rft.issue=8&rft.spage=1219&rft.epage=1225&rft.pages=1219-1225&rft.issn=0007-0920&rft.eissn=1532-1827&rft.coden=BJCAAI&rft_id=info:doi/10.1054/bjoc.2001.2024&rft_dat=%3Cproquest_pubme%3E954574856%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=229963608&rft_id=info:pmid/11710838&rfr_iscdi=true |