Is there loss or qualitative changes in the expression of thyroid peroxidase protein in thyroid epithelial cancer?
There is disagreement concerning the expression of thyroid peroxidase (TPO) in thyroid cancer, some studies finding qualitative as well as quantitative differences compared to normal tissue. To investigate TPO protein expression and its antigenic properties, TPO was captured from a solubilizate of t...
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| Veröffentlicht in: | British journal of cancer 2001-09, Vol.85 (6), p.875-880 |
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| creator | Czarnocka, B Pastuszko, D Janota-Bzowski, M Weetman, A P Watson, P F Kemp, E H McIntosh, R S Asghar, M S Jarzab, B Gubala, E Wloch, J Lange, D |
| description | There is disagreement concerning the expression of thyroid peroxidase (TPO) in thyroid cancer, some studies finding qualitative as well as quantitative differences compared to normal tissue. To investigate TPO protein expression and its antigenic properties, TPO was captured from a solubilizate of thyroid microsomes by a panel of murine anti-TPO monoclonal antibodies and detected with a panel of anti-human TPO IgGκ Fab. TPO protein expression in 30 samples of malignant thyroid tissue was compared with TPO from adjacent normal tissues. Virtual absence of TPO expression was observed in 8 cases. In the remaining 22 malignant thyroid tumours the TPO protein level varied considerably from normal to nearly absent when compared to normal thyroid tissue or tissues from patients with Graves’ disease (range less than 0.5 to more than 12.5 μg mg
–1
of protein). When expressed TPO displayed similar epitopes, to that of TPO from Graves’ disease tissue. The results obtained by the TPO capturing method were confirmed by SDS-PAGE and Western blot analysis with both microsomes and their solubilizates. The present results show that in about two-thirds of differentiated thyroid carcinomas, TPO protein is expressed, albeit to a more variable extent than normal; when present, TPO in malignant tissues is immunologically normal. © 2001 Cancer Research Campaign
http://www.bjcancer.com |
| doi_str_mv | 10.1054/bjoc.2001.2015 |
| format | Article |
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–1
of protein). When expressed TPO displayed similar epitopes, to that of TPO from Graves’ disease tissue. The results obtained by the TPO capturing method were confirmed by SDS-PAGE and Western blot analysis with both microsomes and their solubilizates. The present results show that in about two-thirds of differentiated thyroid carcinomas, TPO protein is expressed, albeit to a more variable extent than normal; when present, TPO in malignant tissues is immunologically normal. © 2001 Cancer Research Campaign
http://www.bjcancer.com</description><identifier>ISSN: 0007-0920</identifier><identifier>EISSN: 1532-1827</identifier><identifier>DOI: 10.1054/bjoc.2001.2015</identifier><identifier>PMID: 11556840</identifier><identifier>CODEN: BJCAAI</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Adenocarcinoma, Follicular - enzymology ; Adenocarcinoma, Follicular - immunology ; Adolescent ; Adult ; Aged ; Antibodies, Monoclonal ; Biological and medical sciences ; Biomedical and Life Sciences ; Biomedicine ; Blotting, Western ; Cancer Research ; Carcinoma, Papillary - enzymology ; Carcinoma, Papillary - immunology ; Drug Resistance ; Electrophoresis, Polyacrylamide Gel ; Endocrinopathies ; Epidemiology ; Epitope Mapping ; Female ; Gene Expression Regulation, Neoplastic ; Graves Disease - enzymology ; Humans ; Immunoenzyme Techniques ; Iodide Peroxidase - metabolism ; Male ; Malignant tumors ; Medical sciences ; Microsomes - enzymology ; Microsomes - immunology ; Middle Aged ; Molecular Medicine ; Oncology ; Regular ; regular-article ; Thyroid Diseases - enzymology ; Thyroid Gland - enzymology ; Thyroid Neoplasms - enzymology ; Thyroid Neoplasms - immunology ; Thyroid. Thyroid axis (diseases)</subject><ispartof>British journal of cancer, 2001-09, Vol.85 (6), p.875-880</ispartof><rights>The Author(s) 2001</rights><rights>2002 INIST-CNRS</rights><rights>Copyright 2001 Cancer Research Campaign http://www.bjcancer.com.</rights><rights>Copyright Nature Publishing Group Sep 2001</rights><rights>Copyright © 2001 Cancer Research Campaign 2001 Cancer Research Campaign</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c483t-60298e03d5ed4339c752f5ff8092b915151d87b666d7429eaf9092bf2389f8eb3</citedby><cites>FETCH-LOGICAL-c483t-60298e03d5ed4339c752f5ff8092b915151d87b666d7429eaf9092bf2389f8eb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2375069/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2375069/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,41464,42533,51294,53766,53768</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14111897$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11556840$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Czarnocka, B</creatorcontrib><creatorcontrib>Pastuszko, D</creatorcontrib><creatorcontrib>Janota-Bzowski, M</creatorcontrib><creatorcontrib>Weetman, A P</creatorcontrib><creatorcontrib>Watson, P F</creatorcontrib><creatorcontrib>Kemp, E H</creatorcontrib><creatorcontrib>McIntosh, R S</creatorcontrib><creatorcontrib>Asghar, M S</creatorcontrib><creatorcontrib>Jarzab, B</creatorcontrib><creatorcontrib>Gubala, E</creatorcontrib><creatorcontrib>Wloch, J</creatorcontrib><creatorcontrib>Lange, D</creatorcontrib><title>Is there loss or qualitative changes in the expression of thyroid peroxidase protein in thyroid epithelial cancer?</title><title>British journal of cancer</title><addtitle>Br J Cancer</addtitle><addtitle>Br J Cancer</addtitle><description>There is disagreement concerning the expression of thyroid peroxidase (TPO) in thyroid cancer, some studies finding qualitative as well as quantitative differences compared to normal tissue. To investigate TPO protein expression and its antigenic properties, TPO was captured from a solubilizate of thyroid microsomes by a panel of murine anti-TPO monoclonal antibodies and detected with a panel of anti-human TPO IgGκ Fab. TPO protein expression in 30 samples of malignant thyroid tissue was compared with TPO from adjacent normal tissues. Virtual absence of TPO expression was observed in 8 cases. In the remaining 22 malignant thyroid tumours the TPO protein level varied considerably from normal to nearly absent when compared to normal thyroid tissue or tissues from patients with Graves’ disease (range less than 0.5 to more than 12.5 μg mg
–1
of protein). When expressed TPO displayed similar epitopes, to that of TPO from Graves’ disease tissue. The results obtained by the TPO capturing method were confirmed by SDS-PAGE and Western blot analysis with both microsomes and their solubilizates. The present results show that in about two-thirds of differentiated thyroid carcinomas, TPO protein is expressed, albeit to a more variable extent than normal; when present, TPO in malignant tissues is immunologically normal. © 2001 Cancer Research Campaign
http://www.bjcancer.com</description><subject>Adenocarcinoma, Follicular - enzymology</subject><subject>Adenocarcinoma, Follicular - immunology</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Antibodies, Monoclonal</subject><subject>Biological and medical sciences</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Blotting, Western</subject><subject>Cancer Research</subject><subject>Carcinoma, Papillary - enzymology</subject><subject>Carcinoma, Papillary - immunology</subject><subject>Drug Resistance</subject><subject>Electrophoresis, Polyacrylamide Gel</subject><subject>Endocrinopathies</subject><subject>Epidemiology</subject><subject>Epitope Mapping</subject><subject>Female</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Graves Disease - enzymology</subject><subject>Humans</subject><subject>Immunoenzyme Techniques</subject><subject>Iodide Peroxidase - metabolism</subject><subject>Male</subject><subject>Malignant tumors</subject><subject>Medical sciences</subject><subject>Microsomes - enzymology</subject><subject>Microsomes - immunology</subject><subject>Middle Aged</subject><subject>Molecular Medicine</subject><subject>Oncology</subject><subject>Regular</subject><subject>regular-article</subject><subject>Thyroid Diseases - enzymology</subject><subject>Thyroid Gland - enzymology</subject><subject>Thyroid Neoplasms - enzymology</subject><subject>Thyroid Neoplasms - immunology</subject><subject>Thyroid. 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To investigate TPO protein expression and its antigenic properties, TPO was captured from a solubilizate of thyroid microsomes by a panel of murine anti-TPO monoclonal antibodies and detected with a panel of anti-human TPO IgGκ Fab. TPO protein expression in 30 samples of malignant thyroid tissue was compared with TPO from adjacent normal tissues. Virtual absence of TPO expression was observed in 8 cases. In the remaining 22 malignant thyroid tumours the TPO protein level varied considerably from normal to nearly absent when compared to normal thyroid tissue or tissues from patients with Graves’ disease (range less than 0.5 to more than 12.5 μg mg
–1
of protein). When expressed TPO displayed similar epitopes, to that of TPO from Graves’ disease tissue. The results obtained by the TPO capturing method were confirmed by SDS-PAGE and Western blot analysis with both microsomes and their solubilizates. The present results show that in about two-thirds of differentiated thyroid carcinomas, TPO protein is expressed, albeit to a more variable extent than normal; when present, TPO in malignant tissues is immunologically normal. © 2001 Cancer Research Campaign
http://www.bjcancer.com</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>11556840</pmid><doi>10.1054/bjoc.2001.2015</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | British journal of cancer, 2001-09, Vol.85 (6), p.875-880 |
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| source | MEDLINE; Springer Nature - Complete Springer Journals; Nature; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Adenocarcinoma, Follicular - enzymology Adenocarcinoma, Follicular - immunology Adolescent Adult Aged Antibodies, Monoclonal Biological and medical sciences Biomedical and Life Sciences Biomedicine Blotting, Western Cancer Research Carcinoma, Papillary - enzymology Carcinoma, Papillary - immunology Drug Resistance Electrophoresis, Polyacrylamide Gel Endocrinopathies Epidemiology Epitope Mapping Female Gene Expression Regulation, Neoplastic Graves Disease - enzymology Humans Immunoenzyme Techniques Iodide Peroxidase - metabolism Male Malignant tumors Medical sciences Microsomes - enzymology Microsomes - immunology Middle Aged Molecular Medicine Oncology Regular regular-article Thyroid Diseases - enzymology Thyroid Gland - enzymology Thyroid Neoplasms - enzymology Thyroid Neoplasms - immunology Thyroid. Thyroid axis (diseases) |
| title | Is there loss or qualitative changes in the expression of thyroid peroxidase protein in thyroid epithelial cancer? |
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