Rutoside decreases human macrophage-derived inflammatory mediators and improves clinical signs in adjuvant-induced arthritis

Dietary flavonols may play an important role in the adjunct therapy of chronic inflammation. The availability of therapeutic formulations of pentahydroxyflavone glycoside, rutoside (RU), led us to investigate the ability of this molecule to modulate the release of various proinflammatory mediators f...

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Veröffentlicht in:	Arthritis research & therapy 2008-01, Vol.10 (1), p.R19-R19, Article R19
Hauptverfasser:	Kauss, Tina, Moynet, Daniel, Rambert, Jérôme, Al-Kharrat, Abir, Brajot, Stephane, Thiolat, Denis, Ennemany, Rachid, Fawaz, Fawaz, Mossalayi, M Djavad
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arthritis Arthritis, Experimental - genetics Arthritis, Experimental - metabolism Arthritis, Experimental - pathology Arthritis, Experimental - physiopathology Body Weight - drug effects Care and treatment Cells, Cultured Chronic Disease Cytokines - antagonists & inhibitors Cytokines - genetics Dose-Response Relationship, Drug Female Health aspects Humans Inflammation Inflammation Mediators - antagonists & inhibitors Interleukin-1 - antagonists & inhibitors Interleukin-6 - antagonists & inhibitors Macrophages - drug effects Macrophages - metabolism Macrophages, Peritoneal - drug effects Macrophages, Peritoneal - metabolism Nitric Oxide - antagonists & inhibitors Rats Rats, Inbred Lew Rutin - administration & dosage Rutin - pharmacology Transcription, Genetic - drug effects Tumor Necrosis Factor-alpha - antagonists & inhibitors
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