Molecular confinement influences protein structure and enhances thermal protein stability

The sol‐gel method of encapsulating proteins in a silica matrix was investigated as a potential experimental system for testing the effects of molecular confinement on the structure and stability of proteins. We demonstrate that silica entrapment (1) is fully compatible with structure analysis by ci...

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Veröffentlicht in:	Protein science 2001-02, Vol.10 (2), p.250-261
Hauptverfasser:	Eggers, Daryl K., Valentine, Joan S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals apomyoglobin Apoproteins - chemistry Calcium - pharmacology Cattle Chickens Circular Dichroism Dithiothreitol - pharmacology Edetic Acid - pharmacology Hofmeister effect Horses Hydrogen-Ion Concentration Ions Lactalbumin - chemistry macromolecular crowding Metmyoglobin - chemistry Muramidase - chemistry Myoglobin - chemistry Potassium Chloride - pharmacology Protein Binding Protein Conformation Protein Denaturation Protein folding Protein Structure, Secondary Protein Structure, Tertiary Silica Gel Silicon Dioxide - chemistry sol‐gel glass Temperature Ultraviolet Rays
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