IL-6-dependent spontaneous proliferation is required for the induction of colitogenic IL-17-producing CD8+ T cells

We propose a novel role for interleukin (IL) 6 in inducing rapid spontaneous proliferation (SP) of naive CD8(+) T cells, which is a crucial step in the differentiation of colitogenic CD8(+) T cells. Homeostasis of T cells is regulated by two distinct modes of cell proliferation: major histocompatibi...

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Veröffentlicht in:	The Journal of experimental medicine 2008-05, Vol.205 (5), p.1019-1027
Hauptverfasser:	Tajima, Masaki, Wakita, Daiko, Noguchi, Daisuke, Chamoto, Kenji, Yue, Zhang, Fugo, Kazunori, Ishigame, Harumichi, Iwakura, Yoichiro, Kitamura, Hidemitsu, Nishimura, Takashi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adoptive Transfer Animals Autoimmune Diseases - immunology Brief Definitive Reports CD8-Positive T-Lymphocytes - immunology Cell Division Colitis - immunology DNA-Binding Proteins - deficiency Immunologic Memory Interleukin-17 - biosynthesis Interleukin-6 - immunology Kinetics Major Histocompatibility Complex Mice Mice, Knockout
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