Axons of retinal ganglion cells are insulted in the optic nerve early in DBA/2J glaucoma

Here, we use a mouse model (DBA/2J) to readdress the location of insult(s) to retinal ganglion cells (RGCs) in glaucoma. We localize an early sign of axon damage to an astrocyte-rich region of the optic nerve just posterior to the retina, analogous to the lamina cribrosa. In this region, a network o...

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Veröffentlicht in:	The Journal of cell biology 2007-12, Vol.179 (7), p.1523-1537
Hauptverfasser:	Howell, Gareth R, Libby, Richard T, Jakobs, Tatjana C, Smith, Richard S, Phalan, F. Campbell, Barter, Joseph W, Barbay, Jessica M, Marchant, Jeffrey K, Mahesh, Nagaraju, Porciatti, Vittorio, Whitmore, Alan V, Masland, Richard H, John, Simon W.M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Astrocytes Axons Axons - pathology bcl-2-Associated X Protein - genetics Brain damage Cellular biology Cytoprotection - genetics Disease Models, Animal Disease Progression Electroretinography Eyes Female Glaucoma Glaucoma - complications Glaucoma - pathology Glaucoma - physiopathology Insults Male Mice Mice, Inbred C57BL Mice, Inbred DBA Mice, Knockout Mice, Neurologic Mutants Mice, Transgenic Mutation - genetics Nerves Neurites Neurons Optic nerve Optic Nerve Diseases - etiology Optic Nerve Diseases - pathology Optic Nerve Diseases - physiopathology Retina Retinal Degeneration - etiology Retinal Degeneration - pathology Retinal Degeneration - physiopathology Retinal Ganglion Cells - pathology Rodents Time Factors Wallerian Degeneration - etiology Wallerian Degeneration - pathology Wallerian Degeneration - physiopathology
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