Magnitude and direction of DNA bending induced by screw-axis orientation: influence of sequence, mismatches and abasic sites

DNA-bending flexibility is central for its many biological functions. A new bending restraining method for use in molecular mechanics calculations and molecular dynamics simulations was developed. It is based on an average screw rotation axis definition for DNA segments and allows inducing continuou...

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Veröffentlicht in:	Nucleic acids research 2008-04, Vol.36 (7), p.2268-2283
Hauptverfasser:	Curuksu, Jeremy, Zakrzewska, Krystyna, Zacharias, Martin
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Pair Mismatch Base Sequence Biochemistry, Molecular Biology Computational Biology Computer Simulation DNA - chemistry DNA Damage Life Sciences Models, Molecular Nucleic Acid Conformation Oligodeoxyribonucleotides - chemistry
Online-Zugang:	Volltext
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