Prenatal Organochlorine Exposure and Measures of Behavior in Infancy Using the Neonatal Behavioral Assessment Scale (NBAS)
Background: Previous literature suggests an association between organochlorines and behavioral measures in childhood, including inattention. Objective: This study was designed to assess whether prenatal organochlorine exposure is associated with measures of attention in early infancy. Methods: We in...
Gespeichert in:
| Veröffentlicht in: | Environmental health perspectives 2008-05, Vol.116 (5), p.666-673 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 673 |
|---|---|
| container_issue | 5 |
| container_start_page | 666 |
| container_title | Environmental health perspectives |
| container_volume | 116 |
| creator | Sagiv, Sharon K. Nugent, J. Kevin Brazelton, T. Berry Choi, Anna L. Tolbert, Paige E. Altshul, Larisa M. Korrick, Susan A. |
| description | Background: Previous literature suggests an association between organochlorines and behavioral measures in childhood, including inattention. Objective: This study was designed to assess whether prenatal organochlorine exposure is associated with measures of attention in early infancy. Methods: We investigated an association between cord serum polychlorinated biphenyls (PCBs) and p,p'-dichlorodiphenyl dichloroethene (DDE) levels and measures of attention from the Neonatal Behavioral Assessment Scale (NBAS) in a cohort of 788 infants born 1993-1998 to mothers residing near a PCB-contaminated harbor and Superfund site in New Bedford, Massachusetts. Results: Medians (ranges) for the sum of four prevalent PCB congeners and DDE levels were 0.19 (0.01-4.41) and 0.30 (0-10.29) ng/g serum, respectively. For the 542 subjects with an NBAS exam at 2 weeks, we observed consistent inverse associations between cord serum PCB and DDE levels and NBAS measures of alertness, quality of alert responsiveness, cost of attention, and other potential attention-associated measures including self-quieting and motor maturity. For example, the decrement in quality of alert responsiveness score was -0.51 (95% confidence interval, -0.99 to -0.03) for the highest quartile of exposure to the sum of four prevalent PCB congeners compared with the lowest quartile. We found little evidence for an association with infant orientation, habituation, and regulation of state, assessed as summary cluster measures. Conclusions: Our findings provide evidence for an association between low-level prenatal PCB and DDE exposures and poor attention in early infancy. Further analyses will focus on whether organochlorine-associated decrements in attention and attention-related skills in infancy persist in later childhood. |
| doi_str_mv | 10.1289/ehp.10553 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2367684</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A179234000</galeid><jstor_id>25067937</jstor_id><sourcerecordid>A179234000</sourcerecordid><originalsourceid>FETCH-LOGICAL-c664t-261bdc8ea1a0f0c74685859f1e6c9ffd74dd89322f7a9cdd6c6c5b3ed5ede5603</originalsourceid><addsrcrecordid>eNqNklFv0zAQxyMEYmXwwAcAWTxM7CHFdmIneUHqpgGVxooo49VynXPiKrWLnUwbnx6XlrGiPiA_-OT73f_Od5ckLwkeE1pW76BdjwlmLHuUjAhjNK0qmj9ORhhXJOUFZ0fJsxCWGGNScv40OSJlXuCM4lHy84sHK3vZoZlvpHWq7Zw3FtDF7dqFwQOStkafQW7sgJxGZ9DKG-M8MhZNrZZW3aHrYGyD-hbQFbit3B8smpMQIIQV2B7NlewAvb06m8xPnydPtOwCvNjdx8n1h4tv55_Sy9nH6fnkMlWc531KOVnUqgRJJNZYFTkvWckqTYCrSuu6yOu6rDJKdSErVddcccUWGdQMamAcZ8fJ-63uelisoFaxjliVWHuzkv5OOGnEvseaVjTuRtAs9q7Mo8DJTsC7HwOEXqxMUNB10oIbgqCYV4TSLIJv_gGXbvA2fk5QSnkei9yopVuoia0QxmoXk6oGLMTczoI28XlCiopmeZxY5McH-HhqWBl1MOB0LyAyPdz2jRxCENP51_9nZ9_32ZMHbAuy69vguqE3zoaDosq7EDzo-14TLDYLK-LCit8LG9nXD4fzl9xtaARebYFl6J2_91OGeVFlRfYLCpPuKQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>222643224</pqid></control><display><type>article</type><title>Prenatal Organochlorine Exposure and Measures of Behavior in Infancy Using the Neonatal Behavioral Assessment Scale (NBAS)</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>PubMed Central Open Access</source><source>JSTOR Archive Collection A-Z Listing</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Sagiv, Sharon K. ; Nugent, J. Kevin ; Brazelton, T. Berry ; Choi, Anna L. ; Tolbert, Paige E. ; Altshul, Larisa M. ; Korrick, Susan A.</creator><creatorcontrib>Sagiv, Sharon K. ; Nugent, J. Kevin ; Brazelton, T. Berry ; Choi, Anna L. ; Tolbert, Paige E. ; Altshul, Larisa M. ; Korrick, Susan A.</creatorcontrib><description>Background: Previous literature suggests an association between organochlorines and behavioral measures in childhood, including inattention. Objective: This study was designed to assess whether prenatal organochlorine exposure is associated with measures of attention in early infancy. Methods: We investigated an association between cord serum polychlorinated biphenyls (PCBs) and p,p'-dichlorodiphenyl dichloroethene (DDE) levels and measures of attention from the Neonatal Behavioral Assessment Scale (NBAS) in a cohort of 788 infants born 1993-1998 to mothers residing near a PCB-contaminated harbor and Superfund site in New Bedford, Massachusetts. Results: Medians (ranges) for the sum of four prevalent PCB congeners and DDE levels were 0.19 (0.01-4.41) and 0.30 (0-10.29) ng/g serum, respectively. For the 542 subjects with an NBAS exam at 2 weeks, we observed consistent inverse associations between cord serum PCB and DDE levels and NBAS measures of alertness, quality of alert responsiveness, cost of attention, and other potential attention-associated measures including self-quieting and motor maturity. For example, the decrement in quality of alert responsiveness score was -0.51 (95% confidence interval, -0.99 to -0.03) for the highest quartile of exposure to the sum of four prevalent PCB congeners compared with the lowest quartile. We found little evidence for an association with infant orientation, habituation, and regulation of state, assessed as summary cluster measures. Conclusions: Our findings provide evidence for an association between low-level prenatal PCB and DDE exposures and poor attention in early infancy. Further analyses will focus on whether organochlorine-associated decrements in attention and attention-related skills in infancy persist in later childhood.</description><identifier>ISSN: 0091-6765</identifier><identifier>EISSN: 1552-9924</identifier><identifier>DOI: 10.1289/ehp.10553</identifier><identifier>PMID: 18470320</identifier><language>eng</language><publisher>United States: National Institute of Environmental Health Sciences. National Institutes of Health. Department of Health, Education and Welfare</publisher><subject>Adult ; Alertness ; Attention - drug effects ; Behavioral assessment ; Chemical hazards ; Childhood ; Children's Health ; Cohort Studies ; Congeners ; DDT (Insecticide) ; Dichlorodiphenyl Dichloroethylene - pharmacology ; Dichlorodiphenyl Dichloroethylene - toxicity ; Environmental Exposure ; Environmental health ; Environmental Pollutants - pharmacology ; Environmental Pollutants - toxicity ; Female ; Fetus ; Growth ; Health aspects ; Humans ; Infancy ; Infant ; Infant Behavior - drug effects ; Infant, Newborn ; Infants ; Male ; Massachusetts ; Organochlorine compounds ; Polychlorinated biphenyls ; Polychlorinated Biphenyls - pharmacology ; Polychlorinated Biphenyls - toxicity ; Pregnancy ; Prenatal Exposure Delayed Effects - physiopathology ; Referents</subject><ispartof>Environmental health perspectives, 2008-05, Vol.116 (5), p.666-673</ispartof><rights>COPYRIGHT 2008 National Institute of Environmental Health Sciences</rights><rights>Copyright National Institute of Environmental Health Sciences May 2008</rights><rights>2008</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c664t-261bdc8ea1a0f0c74685859f1e6c9ffd74dd89322f7a9cdd6c6c5b3ed5ede5603</citedby><cites>FETCH-LOGICAL-c664t-261bdc8ea1a0f0c74685859f1e6c9ffd74dd89322f7a9cdd6c6c5b3ed5ede5603</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/25067937$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/25067937$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,727,780,784,803,864,885,27924,27925,53791,53793,58017,58250</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18470320$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sagiv, Sharon K.</creatorcontrib><creatorcontrib>Nugent, J. Kevin</creatorcontrib><creatorcontrib>Brazelton, T. Berry</creatorcontrib><creatorcontrib>Choi, Anna L.</creatorcontrib><creatorcontrib>Tolbert, Paige E.</creatorcontrib><creatorcontrib>Altshul, Larisa M.</creatorcontrib><creatorcontrib>Korrick, Susan A.</creatorcontrib><title>Prenatal Organochlorine Exposure and Measures of Behavior in Infancy Using the Neonatal Behavioral Assessment Scale (NBAS)</title><title>Environmental health perspectives</title><addtitle>Environ Health Perspect</addtitle><description>Background: Previous literature suggests an association between organochlorines and behavioral measures in childhood, including inattention. Objective: This study was designed to assess whether prenatal organochlorine exposure is associated with measures of attention in early infancy. Methods: We investigated an association between cord serum polychlorinated biphenyls (PCBs) and p,p'-dichlorodiphenyl dichloroethene (DDE) levels and measures of attention from the Neonatal Behavioral Assessment Scale (NBAS) in a cohort of 788 infants born 1993-1998 to mothers residing near a PCB-contaminated harbor and Superfund site in New Bedford, Massachusetts. Results: Medians (ranges) for the sum of four prevalent PCB congeners and DDE levels were 0.19 (0.01-4.41) and 0.30 (0-10.29) ng/g serum, respectively. For the 542 subjects with an NBAS exam at 2 weeks, we observed consistent inverse associations between cord serum PCB and DDE levels and NBAS measures of alertness, quality of alert responsiveness, cost of attention, and other potential attention-associated measures including self-quieting and motor maturity. For example, the decrement in quality of alert responsiveness score was -0.51 (95% confidence interval, -0.99 to -0.03) for the highest quartile of exposure to the sum of four prevalent PCB congeners compared with the lowest quartile. We found little evidence for an association with infant orientation, habituation, and regulation of state, assessed as summary cluster measures. Conclusions: Our findings provide evidence for an association between low-level prenatal PCB and DDE exposures and poor attention in early infancy. Further analyses will focus on whether organochlorine-associated decrements in attention and attention-related skills in infancy persist in later childhood.</description><subject>Adult</subject><subject>Alertness</subject><subject>Attention - drug effects</subject><subject>Behavioral assessment</subject><subject>Chemical hazards</subject><subject>Childhood</subject><subject>Children's Health</subject><subject>Cohort Studies</subject><subject>Congeners</subject><subject>DDT (Insecticide)</subject><subject>Dichlorodiphenyl Dichloroethylene - pharmacology</subject><subject>Dichlorodiphenyl Dichloroethylene - toxicity</subject><subject>Environmental Exposure</subject><subject>Environmental health</subject><subject>Environmental Pollutants - pharmacology</subject><subject>Environmental Pollutants - toxicity</subject><subject>Female</subject><subject>Fetus</subject><subject>Growth</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Infancy</subject><subject>Infant</subject><subject>Infant Behavior - drug effects</subject><subject>Infant, Newborn</subject><subject>Infants</subject><subject>Male</subject><subject>Massachusetts</subject><subject>Organochlorine compounds</subject><subject>Polychlorinated biphenyls</subject><subject>Polychlorinated Biphenyls - pharmacology</subject><subject>Polychlorinated Biphenyls - toxicity</subject><subject>Pregnancy</subject><subject>Prenatal Exposure Delayed Effects - physiopathology</subject><subject>Referents</subject><issn>0091-6765</issn><issn>1552-9924</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNklFv0zAQxyMEYmXwwAcAWTxM7CHFdmIneUHqpgGVxooo49VynXPiKrWLnUwbnx6XlrGiPiA_-OT73f_Od5ckLwkeE1pW76BdjwlmLHuUjAhjNK0qmj9ORhhXJOUFZ0fJsxCWGGNScv40OSJlXuCM4lHy84sHK3vZoZlvpHWq7Zw3FtDF7dqFwQOStkafQW7sgJxGZ9DKG-M8MhZNrZZW3aHrYGyD-hbQFbit3B8smpMQIIQV2B7NlewAvb06m8xPnydPtOwCvNjdx8n1h4tv55_Sy9nH6fnkMlWc531KOVnUqgRJJNZYFTkvWckqTYCrSuu6yOu6rDJKdSErVddcccUWGdQMamAcZ8fJ-63uelisoFaxjliVWHuzkv5OOGnEvseaVjTuRtAs9q7Mo8DJTsC7HwOEXqxMUNB10oIbgqCYV4TSLIJv_gGXbvA2fk5QSnkei9yopVuoia0QxmoXk6oGLMTczoI28XlCiopmeZxY5McH-HhqWBl1MOB0LyAyPdz2jRxCENP51_9nZ9_32ZMHbAuy69vguqE3zoaDosq7EDzo-14TLDYLK-LCit8LG9nXD4fzl9xtaARebYFl6J2_91OGeVFlRfYLCpPuKQ</recordid><startdate>20080501</startdate><enddate>20080501</enddate><creator>Sagiv, Sharon K.</creator><creator>Nugent, J. Kevin</creator><creator>Brazelton, T. Berry</creator><creator>Choi, Anna L.</creator><creator>Tolbert, Paige E.</creator><creator>Altshul, Larisa M.</creator><creator>Korrick, Susan A.</creator><general>National Institute of Environmental Health Sciences. National Institutes of Health. Department of Health, Education and Welfare</general><general>National Institute of Environmental Health Sciences</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>4T-</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FG</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>L6V</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7S</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PATMY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>S0X</scope><scope>7T2</scope><scope>7TV</scope><scope>7U2</scope><scope>7U7</scope><scope>C1K</scope><scope>5PM</scope></search><sort><creationdate>20080501</creationdate><title>Prenatal Organochlorine Exposure and Measures of Behavior in Infancy Using the Neonatal Behavioral Assessment Scale (NBAS)</title><author>Sagiv, Sharon K. ; Nugent, J. Kevin ; Brazelton, T. Berry ; Choi, Anna L. ; Tolbert, Paige E. ; Altshul, Larisa M. ; Korrick, Susan A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c664t-261bdc8ea1a0f0c74685859f1e6c9ffd74dd89322f7a9cdd6c6c5b3ed5ede5603</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adult</topic><topic>Alertness</topic><topic>Attention - drug effects</topic><topic>Behavioral assessment</topic><topic>Chemical hazards</topic><topic>Childhood</topic><topic>Children's Health</topic><topic>Cohort Studies</topic><topic>Congeners</topic><topic>DDT (Insecticide)</topic><topic>Dichlorodiphenyl Dichloroethylene - pharmacology</topic><topic>Dichlorodiphenyl Dichloroethylene - toxicity</topic><topic>Environmental Exposure</topic><topic>Environmental health</topic><topic>Environmental Pollutants - pharmacology</topic><topic>Environmental Pollutants - toxicity</topic><topic>Female</topic><topic>Fetus</topic><topic>Growth</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Infancy</topic><topic>Infant</topic><topic>Infant Behavior - drug effects</topic><topic>Infant, Newborn</topic><topic>Infants</topic><topic>Male</topic><topic>Massachusetts</topic><topic>Organochlorine compounds</topic><topic>Polychlorinated biphenyls</topic><topic>Polychlorinated Biphenyls - pharmacology</topic><topic>Polychlorinated Biphenyls - toxicity</topic><topic>Pregnancy</topic><topic>Prenatal Exposure Delayed Effects - physiopathology</topic><topic>Referents</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sagiv, Sharon K.</creatorcontrib><creatorcontrib>Nugent, J. Kevin</creatorcontrib><creatorcontrib>Brazelton, T. Berry</creatorcontrib><creatorcontrib>Choi, Anna L.</creatorcontrib><creatorcontrib>Tolbert, Paige E.</creatorcontrib><creatorcontrib>Altshul, Larisa M.</creatorcontrib><creatorcontrib>Korrick, Susan A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Docstoc</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Engineering Collection</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Engineering Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>Environmental Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Pollution Abstracts</collection><collection>Safety Science and Risk</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Environmental health perspectives</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sagiv, Sharon K.</au><au>Nugent, J. Kevin</au><au>Brazelton, T. Berry</au><au>Choi, Anna L.</au><au>Tolbert, Paige E.</au><au>Altshul, Larisa M.</au><au>Korrick, Susan A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prenatal Organochlorine Exposure and Measures of Behavior in Infancy Using the Neonatal Behavioral Assessment Scale (NBAS)</atitle><jtitle>Environmental health perspectives</jtitle><addtitle>Environ Health Perspect</addtitle><date>2008-05-01</date><risdate>2008</risdate><volume>116</volume><issue>5</issue><spage>666</spage><epage>673</epage><pages>666-673</pages><issn>0091-6765</issn><eissn>1552-9924</eissn><abstract>Background: Previous literature suggests an association between organochlorines and behavioral measures in childhood, including inattention. Objective: This study was designed to assess whether prenatal organochlorine exposure is associated with measures of attention in early infancy. Methods: We investigated an association between cord serum polychlorinated biphenyls (PCBs) and p,p'-dichlorodiphenyl dichloroethene (DDE) levels and measures of attention from the Neonatal Behavioral Assessment Scale (NBAS) in a cohort of 788 infants born 1993-1998 to mothers residing near a PCB-contaminated harbor and Superfund site in New Bedford, Massachusetts. Results: Medians (ranges) for the sum of four prevalent PCB congeners and DDE levels were 0.19 (0.01-4.41) and 0.30 (0-10.29) ng/g serum, respectively. For the 542 subjects with an NBAS exam at 2 weeks, we observed consistent inverse associations between cord serum PCB and DDE levels and NBAS measures of alertness, quality of alert responsiveness, cost of attention, and other potential attention-associated measures including self-quieting and motor maturity. For example, the decrement in quality of alert responsiveness score was -0.51 (95% confidence interval, -0.99 to -0.03) for the highest quartile of exposure to the sum of four prevalent PCB congeners compared with the lowest quartile. We found little evidence for an association with infant orientation, habituation, and regulation of state, assessed as summary cluster measures. Conclusions: Our findings provide evidence for an association between low-level prenatal PCB and DDE exposures and poor attention in early infancy. Further analyses will focus on whether organochlorine-associated decrements in attention and attention-related skills in infancy persist in later childhood.</abstract><cop>United States</cop><pub>National Institute of Environmental Health Sciences. National Institutes of Health. Department of Health, Education and Welfare</pub><pmid>18470320</pmid><doi>10.1289/ehp.10553</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0091-6765 |
| ispartof | Environmental health perspectives, 2008-05, Vol.116 (5), p.666-673 |
| issn | 0091-6765 1552-9924 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2367684 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; PubMed Central Open Access; JSTOR Archive Collection A-Z Listing; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Adult Alertness Attention - drug effects Behavioral assessment Chemical hazards Childhood Children's Health Cohort Studies Congeners DDT (Insecticide) Dichlorodiphenyl Dichloroethylene - pharmacology Dichlorodiphenyl Dichloroethylene - toxicity Environmental Exposure Environmental health Environmental Pollutants - pharmacology Environmental Pollutants - toxicity Female Fetus Growth Health aspects Humans Infancy Infant Infant Behavior - drug effects Infant, Newborn Infants Male Massachusetts Organochlorine compounds Polychlorinated biphenyls Polychlorinated Biphenyls - pharmacology Polychlorinated Biphenyls - toxicity Pregnancy Prenatal Exposure Delayed Effects - physiopathology Referents |
| title | Prenatal Organochlorine Exposure and Measures of Behavior in Infancy Using the Neonatal Behavioral Assessment Scale (NBAS) |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-05T09%3A13%3A17IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Prenatal%20Organochlorine%20Exposure%20and%20Measures%20of%20Behavior%20in%20Infancy%20Using%20the%20Neonatal%20Behavioral%20Assessment%20Scale%20(NBAS)&rft.jtitle=Environmental%20health%20perspectives&rft.au=Sagiv,%20Sharon%20K.&rft.date=2008-05-01&rft.volume=116&rft.issue=5&rft.spage=666&rft.epage=673&rft.pages=666-673&rft.issn=0091-6765&rft.eissn=1552-9924&rft_id=info:doi/10.1289/ehp.10553&rft_dat=%3Cgale_pubme%3EA179234000%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=222643224&rft_id=info:pmid/18470320&rft_galeid=A179234000&rft_jstor_id=25067937&rfr_iscdi=true |