Characterization of impurities in the bulk drug lisinopril by liquid chromatography/ion trap spectrometry

Two trace impurities in the bulk drug lisinopril were detected by means of high-performance liquid chromatography coupled with mass spectrometry （HPLC/MS） with a simple and sensitive method suitable for HPLC/MSn analysis. The fragmentation behavior of lisinopfil and the impurities was investigated,...

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Veröffentlicht in:	Journal of Zhejiang University. B. Science 2008-05, Vol.9 (5), p.385-390
Hauptverfasser:	Zhu, Pei-xi, Wang, Dan-hua, Sun, Cui-rong, Shen, Zhi-quan
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry Biomedical and Life Sciences Biomedicine Chromatography Chromatography, High Pressure Liquid - methods Drug Contamination Lisinopril - analysis Magnetic Resonance Spectroscopy Mass spectrometry NMR Nuclear magnetic resonance Spectrometry, Mass, Electrospray Ionization - methods 质谱分析 赖诺普利 高性能液体色谱法
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