Novel coumarin glycoside and phenethyl vanillate from Notopterygium forbesii and their binding affinities for opioid and dopamine receptors

New coumarin glycoside and phenethyl vanillate, along with 17 known compounds, were isolated from Notopterygium forbesii. Falcarindiol showed the highest binding affinities to the opioid and dopamine receptors. Bioactivity-guided fractionation of Notopterygium forbesii has resulted in the isolation...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2008-03, Vol.16 (6), p.3218-3223
Hauptverfasser:	Ma, Zhongze, Xu, Wei, Liu-Chen, Lee-Yuan, Lee, David Y.W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Coumarin Coumarins - chemistry Coumarins - isolation & purification Diynes - chemistry Dopamine receptor Falcarindiol Fatty Alcohols - chemistry General pharmacology Glycosides - chemistry Glycosides - isolation & purification Humans Medical sciences Notopterygium forbesii Opioid receptor Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Protein Binding Receptors, Dopamine - metabolism Receptors, Opioid - metabolism Spectrum Analysis Vanillic Acid - chemistry Vanillic Acid - isolation & purification
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