Decoding protein modifications using top-down mass spectrometry

Top-down mass spectrometry is an emerging technology which strives to preserve the post-translationally modified forms of proteins present in vivo by measuring them intact, rather than measuring peptides produced from them by proteolysis. The top-down technology is beginning to capture the interest...

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Veröffentlicht in:	Nature methods 2007-10, Vol.4 (10), p.817-821
Hauptverfasser:	Siuti, Nertila, Kelleher, Neil L
Format:	Artikel
Sprache:	eng
Schlagworte:	Bioinformatics Biological Microscopy Biological Techniques Biologists Biomedical and Life Sciences Biomedical Engineering/Biotechnology Cellular biology Chromatin - chemistry Conformation Life Sciences Mass spectrometry Mass Spectrometry - methods Membrane Proteins - chemistry Peptides perspective Protein Isoforms - chemistry Protein Processing, Post-Translational Protein-protein interactions Proteins Proteomics Proteomics - methods Research methodology Tandem Mass Spectrometry - methods
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