Boronated pyrimidines and purines as cytotoxic, hypolipidemic and anti-inflammatory agents

Boronated pyrimidines and purines as cytotoxic, hypolipidemic and anti-inflammatory agents

The simple boronated bases, e.g. cytosine, adenine and guanine, containing no sugar residues retained good pharmacological activity as hypolipidemic, anti-neoplastic and anti-inflammatory agents in mice at 8 mg/kg. Their activities were generally identical to their respective nucleoside derivatives....

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Veröffentlicht in:Metal-based drugs 1996, Vol.3 (3), p.155-160
Hauptverfasser: Hall, I H, Burnham, B S, Elkins, A, Sood, A, Powell, W, Tomasz, J, Spielvogel, B F
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container_end_page 160
container_issue 3
container_start_page 155
container_title Metal-based drugs
container_volume 3
creator Hall, I H
Burnham, B S
Elkins, A
Sood, A
Powell, W
Tomasz, J
Spielvogel, B F
description The simple boronated bases, e.g. cytosine, adenine and guanine, containing no sugar residues retained good pharmacological activity as hypolipidemic, anti-neoplastic and anti-inflammatory agents in mice at 8 mg/kg. Their activities were generally identical to their respective nucleoside derivatives. Interestingly the boronated acyclovir derivative was a very potent hypolipidemic agent achieving better activity than clofibrate and lovastatin. The boronated adenine derivatives appeared to have the best anti-inflammatory activity in reducing local edema and analgesic effects. The agents were active against the growth of murine and human leukemias and human HeLa-S(3) suspended uterine carcinoma. Only the boronated adenine derivatives were effective in blocking the growth of human SW480 adenocarcinoma and the KB nasopharynx.
doi_str_mv 10.1155/MBD.1996.155
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title Boronated pyrimidines and purines as cytotoxic, hypolipidemic and anti-inflammatory agents
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