Induction of breast cancer resistance protein by the camptothecin derivative DX-8951f is associated with minor reduction of antitumour activity

DX-8951f (exatecan mesylate), a new water-soluble derivative of camptothecin, is currently being evaluated in phase II clinical trials. Resistance may be acquired when treating cancer patients with DX-8951f. Therefore, we selected a subline of the human ovarian cancer cell line A2780 for resistance...

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Veröffentlicht in:	British journal of cancer 2002-09, Vol.87 (6), p.665-672
Hauptverfasser:	van Hattum, A H, Hoogsteen, I J, Schlüper, H M M, Maliepaard, M, Scheffer, G L, Scheper, R J, Kohlhagen, G, Pommier, Y, Pinedo, H M, Boven, E
Format:	Artikel
Sprache:	eng
Schlagworte:	Acridines - pharmacology Animals Antigens, CD - metabolism Antineoplastic Agents, Phytogenic - administration & dosage Antineoplastic Agents, Phytogenic - therapeutic use ATP Binding Cassette Transporter, Subfamily B, Member 1 - metabolism ATP Binding Cassette Transporter, Subfamily G, Member 2 ATP-Binding Cassette Transporters - metabolism Biomedical and Life Sciences Biomedicine Breast Neoplasms - drug therapy Breast Neoplasms - metabolism Camptothecin - administration & dosage Camptothecin - analogs & derivatives Camptothecin - therapeutic use Cancer Research Cell Division - drug effects Cell Division - physiology DNA Topoisomerases, Type I - genetics DNA Topoisomerases, Type I - metabolism Drug Resistance Drug Resistance, Neoplasm Epidemiology Experimental Therapeutics Female Humans Immunoenzyme Techniques Isoquinolines - pharmacology Membrane Glycoproteins Mice Mice, Nude Molecular Medicine Mutation Neoplasm Proteins - metabolism Neoplasms, Experimental - drug therapy Neoplasms, Experimental - pathology Oncology Ovarian Neoplasms - drug therapy Tetrahydroisoquinolines Tetraspanin 29 Tetrazolium Salts Thiazoles Topoisomerase I Inhibitors Tumor Cells, Cultured - cytology Tumor Cells, Cultured - drug effects
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