Molecular profiles of BRCA1-mutated and matched sporadic breast tumours: relation with clinico-pathological features
About 5–10% of breast cancers are hereditary; a genetically and clinically heterogeneous disease in which several susceptibility genes, including BRCA1, have been identified. While distinct tumour features can be used to estimate the likelihood that a breast tumour is caused by a BRCA1 germline muta...
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| Veröffentlicht in: | British journal of cancer 2001-08, Vol.85 (4), p.538-545 |
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| creator | Berns, E M J J Staveren, I L van Verhoog, L Ouweland, A M W van de Gelder, M Meijer-van Meijers-Heijboer, H Portengen, H Foekens, J A Dorssers, L C J Klijn, J G M |
| description | About 5–10% of breast cancers are hereditary; a genetically and clinically heterogeneous disease in which several susceptibility genes, including BRCA1, have been identified. While distinct tumour features can be used to estimate the likelihood that a breast tumour is caused by a BRCA1 germline mutation it is not yet possible to categorize a BRCA1 mutated tumour. The aim of the present study is to molecularly classify BRCA1 mutated breast cancers by resolving gene expression patterns of BRCA1 and matched sporadic surgical breast tumour specimens. The expression profiles of 6 frozen breast tumour tissues with a proven BRCA1 gene mutation were weighed against those from 12 patients without a known family history but who had similar clinico-pathological characteristics. In addition two fibroblast cultures, the breast cancer cell-line HCC1937 and its corresponding B-lymphoblastoid cell line (heterozygous for mutation BRCA1 5382insC) and an epithelial ovarian cancer cell line (A2780) were studied. Using a high density membrane based array for screening of RNA isolated from these samples and standard algorithms and software, we were able to distinguish subgroups of sporadic cases and a group consisting mainly of BRCA1-mutated breast tumours. Furthermore this pilot analysis revealed a gene cluster that differentially expressed genes related to cell substrate formation, adhesion, migration and cell organization in BRCA1-mutated tumours compared to sporadic breast tumours. © 2001 Cancer Research Campaign
http://www.bjcancer.com |
| doi_str_mv | 10.1054/bjoc.2001.1937 |
| format | Article |
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http://www.bjcancer.com</description><identifier>ISSN: 0007-0920</identifier><identifier>EISSN: 1532-1827</identifier><identifier>DOI: 10.1054/bjoc.2001.1937</identifier><identifier>PMID: 11506493</identifier><identifier>CODEN: BJCAAI</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Biological and medical sciences ; Biomedical and Life Sciences ; Biomedicine ; Breast cancer ; Breast Neoplasms - genetics ; Breast Neoplasms - pathology ; Cancer Research ; Cell Adhesion ; Cell Movement ; DNA Mutational Analysis ; DNA, Complementary - analysis ; Drug Resistance ; Epidemiology ; Female ; Gene Expression Regulation ; Genes, BRCA1 - genetics ; Gynecology. Andrology. Obstetrics ; Humans ; Mammary gland diseases ; Medical sciences ; Molecular Medicine ; Mutation ; Oligonucleotide Array Sequence Analysis ; Oncology ; Ovarian cancer ; Pathology ; Regular ; regular-article ; RNA - analysis ; RNA - genetics ; Tumors</subject><ispartof>British journal of cancer, 2001-08, Vol.85 (4), p.538-545</ispartof><rights>The Author(s) 2001</rights><rights>2002 INIST-CNRS</rights><rights>Copyright 2001 Cancer Research Campaign.</rights><rights>Copyright Nature Publishing Group Aug 2001</rights><rights>Copyright © 2001 Cancer Research Campaign 2001 Cancer Research Campaign</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c570t-328a89513dcb2bf531c1a5ca60bddd9988c4d73b1e4b267b4ea7fde06a74dc0e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2364107/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2364107/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,2727,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14096396$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11506493$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Berns, E M J J</creatorcontrib><creatorcontrib>Staveren, I L van</creatorcontrib><creatorcontrib>Verhoog, L</creatorcontrib><creatorcontrib>Ouweland, A M W van de</creatorcontrib><creatorcontrib>Gelder, M Meijer-van</creatorcontrib><creatorcontrib>Meijers-Heijboer, H</creatorcontrib><creatorcontrib>Portengen, H</creatorcontrib><creatorcontrib>Foekens, J A</creatorcontrib><creatorcontrib>Dorssers, L C J</creatorcontrib><creatorcontrib>Klijn, J G M</creatorcontrib><title>Molecular profiles of BRCA1-mutated and matched sporadic breast tumours: relation with clinico-pathological features</title><title>British journal of cancer</title><addtitle>Br J Cancer</addtitle><addtitle>Br J Cancer</addtitle><description>About 5–10% of breast cancers are hereditary; a genetically and clinically heterogeneous disease in which several susceptibility genes, including BRCA1, have been identified. While distinct tumour features can be used to estimate the likelihood that a breast tumour is caused by a BRCA1 germline mutation it is not yet possible to categorize a BRCA1 mutated tumour. The aim of the present study is to molecularly classify BRCA1 mutated breast cancers by resolving gene expression patterns of BRCA1 and matched sporadic surgical breast tumour specimens. The expression profiles of 6 frozen breast tumour tissues with a proven BRCA1 gene mutation were weighed against those from 12 patients without a known family history but who had similar clinico-pathological characteristics. In addition two fibroblast cultures, the breast cancer cell-line HCC1937 and its corresponding B-lymphoblastoid cell line (heterozygous for mutation BRCA1 5382insC) and an epithelial ovarian cancer cell line (A2780) were studied. Using a high density membrane based array for screening of RNA isolated from these samples and standard algorithms and software, we were able to distinguish subgroups of sporadic cases and a group consisting mainly of BRCA1-mutated breast tumours. Furthermore this pilot analysis revealed a gene cluster that differentially expressed genes related to cell substrate formation, adhesion, migration and cell organization in BRCA1-mutated tumours compared to sporadic breast tumours. © 2001 Cancer Research Campaign
http://www.bjcancer.com</description><subject>Biological and medical sciences</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - genetics</subject><subject>Breast Neoplasms - pathology</subject><subject>Cancer Research</subject><subject>Cell Adhesion</subject><subject>Cell Movement</subject><subject>DNA Mutational Analysis</subject><subject>DNA, Complementary - analysis</subject><subject>Drug Resistance</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Gene Expression Regulation</subject><subject>Genes, BRCA1 - genetics</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Mammary gland diseases</subject><subject>Medical sciences</subject><subject>Molecular Medicine</subject><subject>Mutation</subject><subject>Oligonucleotide Array Sequence Analysis</subject><subject>Oncology</subject><subject>Ovarian cancer</subject><subject>Pathology</subject><subject>Regular</subject><subject>regular-article</subject><subject>RNA - analysis</subject><subject>RNA - genetics</subject><subject>Tumors</subject><issn>0007-0920</issn><issn>1532-1827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkk2LFDEQhoMo7jp69aY0gnrq2Xx1p-NBWAe_YEUQPYfqJD2TId0Zk7TivzezM-yooEIgKeqpt5LKi9BDgpcEN_yi3wa9pBiTJZFM3ELnpGG0Jh0Vt9E5xljUWFJ8hu6ltC2hxJ24i84IaXDLJTtH-UPwVs8eYrWLYXDepioM1atPq0tSj3OGbE0Fk6lGyHpTzmkXIhinqz5aSLnK8xjmmF5U0XrILkzVd5c3lfZucjrUO8ib4MPaafDVYCHP0ab76M4APtkHx32Bvrx5_Xn1rr76-Pb96vKq1o3AuWa0g042hBnd035oGNEEGg0t7o0xUnad5kawnlje01b03IIYjMUtCG40tmyBXh50d3M_WqPtlCN4tYtuhPhDBXDq98zkNmodvinKWk6wKALPjwIxfJ1tymp0SVvvYbJhTko2vBFcCF7IZ_8kBcGScUH-CxIhsaCsK-CTP8BtGfRU5qUolbLtJN23XR4gHUNK0Q43jyNY7Q2i9gZRe4OovUFKweNfR3LCj44owNMjAKn82RBh0i6dOI5ly8paoIsDl0pqWtt4ut5fWz86VEzXLriRbFt5nf8JPjvfpg</recordid><startdate>20010817</startdate><enddate>20010817</enddate><creator>Berns, E M J J</creator><creator>Staveren, I L van</creator><creator>Verhoog, L</creator><creator>Ouweland, A M W van de</creator><creator>Gelder, M Meijer-van</creator><creator>Meijers-Heijboer, H</creator><creator>Portengen, H</creator><creator>Foekens, J A</creator><creator>Dorssers, L C J</creator><creator>Klijn, J G M</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>7U7</scope><scope>C1K</scope><scope>5PM</scope></search><sort><creationdate>20010817</creationdate><title>Molecular profiles of BRCA1-mutated and matched sporadic breast tumours: relation with clinico-pathological features</title><author>Berns, E M J J ; Staveren, I L van ; Verhoog, L ; Ouweland, A M W van de ; Gelder, M Meijer-van ; Meijers-Heijboer, H ; Portengen, H ; Foekens, J A ; Dorssers, L C J ; Klijn, J G M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c570t-328a89513dcb2bf531c1a5ca60bddd9988c4d73b1e4b267b4ea7fde06a74dc0e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Biological and medical sciences</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - genetics</topic><topic>Breast Neoplasms - pathology</topic><topic>Cancer Research</topic><topic>Cell Adhesion</topic><topic>Cell Movement</topic><topic>DNA Mutational Analysis</topic><topic>DNA, Complementary - analysis</topic><topic>Drug Resistance</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Gene Expression Regulation</topic><topic>Genes, BRCA1 - genetics</topic><topic>Gynecology. 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While distinct tumour features can be used to estimate the likelihood that a breast tumour is caused by a BRCA1 germline mutation it is not yet possible to categorize a BRCA1 mutated tumour. The aim of the present study is to molecularly classify BRCA1 mutated breast cancers by resolving gene expression patterns of BRCA1 and matched sporadic surgical breast tumour specimens. The expression profiles of 6 frozen breast tumour tissues with a proven BRCA1 gene mutation were weighed against those from 12 patients without a known family history but who had similar clinico-pathological characteristics. In addition two fibroblast cultures, the breast cancer cell-line HCC1937 and its corresponding B-lymphoblastoid cell line (heterozygous for mutation BRCA1 5382insC) and an epithelial ovarian cancer cell line (A2780) were studied. Using a high density membrane based array for screening of RNA isolated from these samples and standard algorithms and software, we were able to distinguish subgroups of sporadic cases and a group consisting mainly of BRCA1-mutated breast tumours. Furthermore this pilot analysis revealed a gene cluster that differentially expressed genes related to cell substrate formation, adhesion, migration and cell organization in BRCA1-mutated tumours compared to sporadic breast tumours. © 2001 Cancer Research Campaign
http://www.bjcancer.com</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>11506493</pmid><doi>10.1054/bjoc.2001.1937</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Biological and medical sciences Biomedical and Life Sciences Biomedicine Breast cancer Breast Neoplasms - genetics Breast Neoplasms - pathology Cancer Research Cell Adhesion Cell Movement DNA Mutational Analysis DNA, Complementary - analysis Drug Resistance Epidemiology Female Gene Expression Regulation Genes, BRCA1 - genetics Gynecology. Andrology. Obstetrics Humans Mammary gland diseases Medical sciences Molecular Medicine Mutation Oligonucleotide Array Sequence Analysis Oncology Ovarian cancer Pathology Regular regular-article RNA - analysis RNA - genetics Tumors |
| title | Molecular profiles of BRCA1-mutated and matched sporadic breast tumours: relation with clinico-pathological features |
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