Tcf-3 expression and β-catenin mediated transcriptional activation in aggressive fibromatosis (desmoid tumour)

Aggressive fibromatosis harbours mutations resulting in beta-catenin protein stabilization. Primary cell cultures demonstrate constitutive tcf activation in aggressive fibromatosis. Expression and co-immunoprecipitation studies suggest that beta-catenin binds and activates tcf-3 in this tumour. This...

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Veröffentlicht in:	British journal of cancer 2001-07, Vol.85 (1), p.98-101
Hauptverfasser:	TEJPAR, S, LI, C, YU, C, POON, R, DENYS, H, SCIOT, R, VAN CUTSEM, E, CASSIMAN, J. J, ALMAN, B. A
Format:	Artikel
Sprache:	eng
Schlagworte:	b-catenin beta Catenin Biological and medical sciences Cytoskeletal Proteins - genetics Cytoskeletal Proteins - metabolism Cytoskeletal Proteins - physiology Dermatology desmoid tumor Fibromatosis, Aggressive - genetics Fibromatosis, Aggressive - metabolism HMGB Proteins Humans Medical sciences Precipitin Tests Regular TCF Transcription Factors Tcf-3 gene Trans-Activators Transcription Factor 7-Like 1 Protein Transcription Factors - biosynthesis Transcription Factors - metabolism Transcriptional Activation - physiology Tumor Cells, Cultured Tumors of the skin and soft tissue. Premalignant lesions
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Beschreibung
Zusammenfassung:	Aggressive fibromatosis harbours mutations resulting in beta-catenin protein stabilization. Primary cell cultures demonstrate constitutive tcf activation in aggressive fibromatosis. Expression and co-immunoprecipitation studies suggest that beta-catenin binds and activates tcf-3 in this tumour. This is the first demonstration of tcf-3 activation by beta-catenin stabilization in a human neoplastic process.
ISSN:	0007-0920 1532-1827
DOI:	10.1054/bjoc.2001.1857