Immunohistochemical analysis of expression and allelotype of mismatch repair genes ( and ) in bladder cancer

Mutation of human homologues of DNA mismatch repair (MMR) genes in tumours has been shown to be associated with the phenomenon of microsatellite instability (MSI). Several studies have reported the occurrence of MSI in bladder cancer, but evidence of involvement of MMR genes in the pathogenesis of t...

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Veröffentlicht in:	British journal of cancer 2001-02, Vol.84 (3), p.321-328
Hauptverfasser:	Kassem, H Sh, Varley, J M, Hamam, S M, Margison, G P
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing Adult Aged Alleles Allelic Imbalance Biological and medical sciences Biomedical and Life Sciences Biomedicine Bladder cancer Cancer Research Carrier Proteins DNA, Neoplasm - genetics DNA-Binding Proteins Drug Resistance Epidemiology Female Gene Expression Regulation, Neoplastic Humans Immunohistochemistry Loss of Heterozygosity Male Medical sciences Microsatellite Repeats - genetics Middle Aged Molecular Medicine MutL Protein Homolog 1 MutS Homolog 2 Protein Neoplasm Proteins - analysis Neoplasm Proteins - genetics Nephrology. Urinary tract diseases Nuclear Proteins Oncology Polymerase Chain Reaction Proto-Oncogene Proteins - analysis Proto-Oncogene Proteins - genetics Regular regular-article Tumors of the urinary system Urinary Bladder Neoplasms - genetics Urinary Bladder Neoplasms - metabolism Urinary Bladder Neoplasms - pathology Urinary tract. Prostate gland
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