A dominant negative mutation of transforming growth factor- β receptor type II gene in microsatellite stable oesophageal carcinoma

Recent investigations revealed microsatellite instability in colon cancers are associated with mutations of the transforming growth factor-β receptor type II gene (TGF-β RII) that encodes a transmembrane protein containing an intracellular serine/threonine kinase domain. Activation of TGF-β receptor...

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Veröffentlicht in:	British journal of cancer 2000-05, Vol.82 (9), p.1557-1560
Hauptverfasser:	Tanaka, Shinji, Mori, Masaki, Mafune, Ken-ichi, Ohno, Shinji, Sugimachi, Keizo
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Base Sequence Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer Research DNA Primers Drug Resistance Epidemiology Esophageal Neoplasms - genetics Esophagus Gastroenterology. Liver. Pancreas. Abdomen Genes, Dominant Humans Medical sciences Microsatellite Repeats - genetics Molecular Medicine Mutation Oncology Polymerase Chain Reaction Polymorphism, Single-Stranded Conformational Protein-Serine-Threonine Kinases Receptors, Transforming Growth Factor beta - genetics Regular regular-article Tumors
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