Methylene blue in the treatment and prevention of ifosfamide-induced encephalopathy: report of 12 cases and a review of the literature

Ifosfamide is an alkylating agent used in the treatment of a variety of solid tumours. Ten to 15% of patients treated with ifosfamide develop an encephalopathy. Methylene blue (MB) may be used in the treatment of this encephalopathy. The purpose of this study was to evaluate the neuroprotective effe...

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Veröffentlicht in:	British journal of cancer 2000-01, Vol.82 (2), p.291-294
Hauptverfasser:	Pelgrims, J, De Vos, F, Van den Brande, J, Schrijvers, D, Prové, A, Vermorken, J B
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Antineoplastic Agents, Alkylating - adverse effects Antineoplastic Agents, Alkylating - therapeutic use Biological and medical sciences Biomedical and Life Sciences Biomedicine Brain Diseases - chemically induced Brain Diseases - drug therapy Cancer Research Dose-Response Relationship, Drug Drug Resistance Drug toxicity and drugs side effects treatment Enzyme Inhibitors - pharmacology Enzyme Inhibitors - therapeutic use Epidemiology Female Humans Ifosfamide - adverse effects Ifosfamide - therapeutic use Infusions, Intravenous Male Medical sciences Methylene Blue - pharmacology Methylene Blue - therapeutic use Middle Aged Molecular Medicine Neoplasms - drug therapy Oncology Pharmacology. Drug treatments Regular regular-article Toxicity: nervous system and muscle Treatment Outcome
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