Evidence for the differential expression of a variant EGF receptor protein in human prostate cancer

Earlier studies have demonstrated an unexplained depletion of the epidermal growth factor receptor (EGFR) protein expression in prostatic cancer. We now attribute this phenomenon to the presence of a variant EGFR (EGFRvIII) that is highly expressed in malignant prostatic neoplasms. In a retrospectiv...

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Veröffentlicht in:	British journal of cancer 2000-01, Vol.82 (1), p.186-194
Hauptverfasser:	Olapade-Olaopa, E O, Moscatello, D K, MacKay, E H, Horsburgh, T, Sandhu, D P S, Terry, T R, Wong, A J, Habib, F K
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Biological and medical sciences Biomedical and Life Sciences Biomedicine Blotting, Western Cancer Research Cell division Drug Resistance Drug Resistance, Neoplasm Epidemiology Epidermal growth factor Humans Hyperplasia Kinases Ligands Male Medical research Medical sciences Molecular Medicine Neoplasm Proteins - analysis Nephrology. Urinary tract diseases Oncology Phenotype Prostate cancer prostate carcinoma Prostatic Neoplasms - chemistry Protein expression Proteins Receptor, Epidermal Growth Factor - analysis Regular regular-article Retrospective Studies Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - analysis Tumors Tumors of the urinary system Urinary tract. Prostate gland
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