The effects of hyperoxic and hypercarbic gases on tumour blood flow

Carbogen (95% O 2 and 5% CO 2 ) has been used in preference to 100% oxygen (O 2 ) as a radiosensitizer, because it is believed that CO 2 blocks O 2 -induced vasoconstriction. However, recent work suggests that both normal and tumour arterioles of dorsal flap window chambers exhibit the opposite: no...

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Veröffentlicht in:	British Journal of Cancer 1999-04, Vol.80 (1-2), p.117-126
Hauptverfasser:	Dunn, T J, Braun, R D, Rhemus, W E, Rosner, G L, Secomb, T W, Tozer, G M, Chaplin, D J, Dewhirst, M W
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - blood Adenocarcinoma - blood supply Administration, Inhalation Animals Arterioles - drug effects Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer Research Carbon Dioxide - pharmacology Drug Resistance Epidemiology Hemodynamics - drug effects Laser-Doppler Flowmetry Medical sciences Models, Theoretical Molecular Medicine Neoplasm Transplantation Oncology Oxygen - pharmacology Radiation therapy and radiosensitizing agent Radiation-Sensitizing Agents - pharmacology Rats Rats, Inbred F344 Regional Blood Flow - drug effects Regular regular-article Treatment with physical agents Treatment. General aspects Tumor Cells, Cultured Tumors Vasoconstriction - drug effects
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