In vivo and in vitro evaluation of combretastatin A-4 and its sodium phosphate prodrug

Summary The anti-tumour effects and mechanism of action of combretastatin A-4 and its prodrug, combretastatin A-4 disodium phosphate, were examined in subcutaneous and orthotopically transplanted experimental colon tumour models. Additionally, the ability of these compounds to directly interfere wit...

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Veröffentlicht in:	British Journal of Cancer 1999-12, Vol.81 (8), p.1318-1327
Hauptverfasser:	Grosios, K, Holwell, S E, McGown, A T, Pettit, G R, Bibby, M C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer Research Cell Division - drug effects Cells, Cultured Chemotherapy Collagen - metabolism Drug Resistance Drug Screening Assays, Antitumor Epidemiology Humans Medical sciences Mice Mice, Nude Molecular Medicine Neoplasms, Experimental - blood supply Neoplasms, Experimental - pathology Neovascularization, Pathologic - drug therapy Oncology Pharmacology. Drug treatments Prodrugs - pharmacology Prodrugs - therapeutic use Regular regular-article Stilbenes - pharmacology Stilbenes - therapeutic use
Online-Zugang:	Volltext
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