Photodynamic therapy with mTHPC and polyethylene glycol-derived mTHPC: a comparative study on human tumour xenografts

Summary The photosensitizing properties of m-tetrahydroxyphenylchlorin (mTHPC) and polyethylene glycol-derivatized mTHPC (pegylated mTHPC) were compared in nude mice bearing human malignant mesothelioma, squamous cell carcinoma and adenocarcinoma xenografts. Laser light (20 J/cm 2 ) at 652 nm was de...

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Veröffentlicht in:	British journal of cancer 1999-03, Vol.79 (7), p.1061-1066
Hauptverfasser:	Ris, H-B, Krueger, T, Giger, A, Lim, C K, Stewart, J C M, Althaus, U, Altermatt, H J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - drug therapy Adenocarcinoma - metabolism Animals Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacokinetics Antineoplastic Agents - therapeutic use Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer Research Carcinoma, Squamous Cell - drug therapy Carcinoma, Squamous Cell - metabolism Dermatitis, Phototoxic - etiology Dermatitis, Phototoxic - pathology Drug Resistance Epidemiology Humans Medical sciences Mesoporphyrins - chemistry Mesoporphyrins - pharmacokinetics Mesoporphyrins - therapeutic use Mesothelioma - drug therapy Mesothelioma - metabolism Mice Mice, Inbred BALB C Mice, Nude Molecular Medicine Neoplasms - drug therapy Neoplasms - metabolism Oncology Photochemotherapy - methods Photoradiation therapy and photosensitizing agent Polyethylene Glycols - chemistry Polyethylene Glycols - pharmacokinetics Polyethylene Glycols - therapeutic use Radiation-Sensitizing Agents - chemistry Radiation-Sensitizing Agents - pharmacokinetics Radiation-Sensitizing Agents - therapeutic use Regular regular-article Transplantation, Heterologous Treatment with physical agents Treatment. General aspects Tumors
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