Dual mechanism of daunorubicin-induced cell death in both sensitive and MDR-resistant HL-60 cells

Summary Exposure of some acute myeloid leukaemia (AML) cells to daunorubicin leads to rapid cell death, whereas other AML cells show natural drug resistance. This has been attributed to expression of functional P-glycoprotein resulting in reduced drug accumulation. However, it has also been proposed...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	British journal of cancer 1999-03, Vol.79 (7-8), p.1090-1097
Hauptverfasser:	Côme, M-G, Skladanowski, A, Larsen, A K, Laurent, G
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics, Antineoplastic - pharmacokinetics Antibiotics, Antineoplastic - pharmacology Antineoplastic agents Apoptosis - genetics Area Under Curve ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer Research Cell Death Daunorubicin - pharmacokinetics Daunorubicin - pharmacology DNA Fragmentation DNA Nucleotidylexotransferase - analysis Dose-Response Relationship, Drug Drug Resistance Drug Resistance, Multiple Drug Resistance, Neoplasm Epidemiology General aspects HL-60 Cells - drug effects HL-60 Cells - metabolism Humans Medical sciences Mitosis Molecular Medicine Neoplasm Proteins - metabolism Oncology Pharmacology. Drug treatments Regular regular-article
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!