Human thyroid cancer cells as a source of iso-genic, iso-phenotypic cell lines with or without functional p53

Summary Differentiated thyroid carcinomas (in contrast to the rarer anaplastic form) are unusual among human cancers in displaying a remarkably low frequency of p53 mutation and appear to retain wild-type (wt) p53 function as assessed by the response of derived cell lines to DNA damage. Using one su...

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