Evaluation of the fibroblast growth factor system as a potential target for therapy in human prostate cancer

Overexpression of fibroblast growth factors (FGFs) has been implicated in prostate carcinogenesis. FGFs function via their high-affinity interactions with receptor tyrosine kinases, FGFR1–4. Expression of FGFR1 and FGFR2 in prostate cancer (CaP) was not found to be associated with clinical parameter...

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Veröffentlicht in:	British journal of cancer 2005-01, Vol.92 (2), p.320-327
Hauptverfasser:	Gowardhan, B, Douglas, D A, Mathers, M E, McKie, A B, McCracken, S R C, Robson, C N, Leung, H Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Antineoplastic Agents, Phytogenic - pharmacology Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer Research Disease-Free Survival Drug Resistance Drug Synergism Drug Therapy, Combination Epidemiology Fibroblast Growth Factors - biosynthesis Humans Immunohistochemistry Male Medical sciences Middle Aged Molecular Diagnostics Molecular Medicine Nephrology. Urinary tract diseases Oncology Paclitaxel - pharmacology Prostatic Hyperplasia - metabolism Prostatic Neoplasms - metabolism Prostatic Neoplasms - mortality Prostatic Neoplasms - therapy Recombinant Fusion Proteins - pharmacology Tumor Cells, Cultured Tumors Tumors of the urinary system Urinary tract. Prostate gland
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