Systemic inflammatory response predicts outcome in patients undergoing resection for ductal adenocarcinoma head of pancreas
The aim of the present study was to examine the relationship between the clinicopathological status, the pre- and postoperative systemic inflammatory response and survival in patients undergoing potentially curative resection for ductal adenocarcinoma of the head of the pancreas. Patients ( n =65) w...
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| Veröffentlicht in: | British journal of cancer 2005-01, Vol.92 (1), p.21-23 |
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| creator | Jamieson, N B Glen, P McMillan, D C McKay, C J Foulis, A K Carter, R Imrie, C W |
| description | The aim of the present study was to examine the relationship between the clinicopathological status, the pre- and postoperative systemic inflammatory response and survival in patients undergoing potentially curative resection for ductal adenocarcinoma of the head of the pancreas. Patients (
n
=65) who underwent resection of ductal adenocarcinoma of the head of pancreas between 1993 and 2001, and had pre- and postoperative measurements of C-reactive protein, were included in the study. The majority of patients had stage III disease (International Union Against Cancer Criteria, IUCC), positive circumferential margin involvement (R
1
), tumour size greater than 25 mm with perineural and lymph node invasion and died within the follow-up period. On multivariate analysis, tumour size (hazard ratio (HR) 2.10, 95% confidence interval (CI) 1.20–3.68,
P
=0.009), vascular invasion (HR 2.58, 95% CI 1.48–4.50,
P
10 mg l
−1
(
P |
| doi_str_mv | 10.1038/sj.bjc.6602305 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2361749</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>971654611</sourcerecordid><originalsourceid>FETCH-LOGICAL-c551t-2aa93416a1e9b309e13a5623dad161d7487fc623b4fde930756d822ea33a5403</originalsourceid><addsrcrecordid>eNp1kc2LFDEQxYMo7rh69SiN4N56Nh_dSeciyOKqsODBvYeapHo2TXcyJt3C4D9vlmkcFTyFSv1e1UseIa8Z3TIquus8bHeD3UpJuaDtE7JhreA167h6SjaUUlVTzekFeZHzUEpNO_WcXLC21YpquSE_vx3zjJO3lQ_9CNMEc0zHKmE-xJCxOiR03s65ists44QFqw4wewzlbgkO0z76sH8UoJ19DFUfU-UWO8NYgcMQLSTrQ5ygekBwVeyLPtiEkF-SZz2MGV-t5yW5v_14f_O5vvv66cvNh7vati2baw6gRcMkMNQ7QTUyAa3kwoFjkjnVdKq3pd41vUMtqGql6zhHEIVrqLgk709jD8tuQmeL9QSjOSQ_QTqaCN783Qn-wezjD8OFZKrRZcDVOiDF7wvm2Uw-WxxHCBiXbKRqmKZKFvDtP-AQlxTK2wznWneUc1ag7QmyKeacsP_thFHzmKnJgymZmjXTInjzp_8zvoZYgHcrANnC2Kfyvz6fOdl0lCleuOsTl0sr7DGd7f1n9S-jzb3y</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>229980221</pqid></control><display><type>article</type><title>Systemic inflammatory response predicts outcome in patients undergoing resection for ductal adenocarcinoma head of pancreas</title><source>MEDLINE</source><source>SpringerLink Journals</source><source>Nature</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><creator>Jamieson, N B ; Glen, P ; McMillan, D C ; McKay, C J ; Foulis, A K ; Carter, R ; Imrie, C W</creator><creatorcontrib>Jamieson, N B ; Glen, P ; McMillan, D C ; McKay, C J ; Foulis, A K ; Carter, R ; Imrie, C W</creatorcontrib><description>The aim of the present study was to examine the relationship between the clinicopathological status, the pre- and postoperative systemic inflammatory response and survival in patients undergoing potentially curative resection for ductal adenocarcinoma of the head of the pancreas. Patients (
n
=65) who underwent resection of ductal adenocarcinoma of the head of pancreas between 1993 and 2001, and had pre- and postoperative measurements of C-reactive protein, were included in the study. The majority of patients had stage III disease (International Union Against Cancer Criteria, IUCC), positive circumferential margin involvement (R
1
), tumour size greater than 25 mm with perineural and lymph node invasion and died within the follow-up period. On multivariate analysis, tumour size (hazard ratio (HR) 2.10, 95% confidence interval (CI) 1.20–3.68,
P
=0.009), vascular invasion (HR 2.58, 95% CI 1.48–4.50,
P
<0.001) and postoperative C-reactive protein (HR 2.00, 95% CI 1.14–3.52,
P
=0.015) retained independent significance. Those patients with a postoperative C-reactive protein ⩽10 mg l
−1
had a median survival of 21.5 months compared with 8.4 months in those patients with a C-reactive protein >10 mg l
−1
(
P
<0.001). The results of the present study indicate that, in patients who have undergone potentially curative resection for ductal adenocarcinoma of the head of pancreas, the presence of a systemic inflammatory response predicts poor outcome.</description><identifier>ISSN: 0007-0920</identifier><identifier>EISSN: 1532-1827</identifier><identifier>DOI: 10.1038/sj.bjc.6602305</identifier><identifier>PMID: 15597096</identifier><identifier>CODEN: BJCAAI</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Aged ; Biological and medical sciences ; Biomedical and Life Sciences ; Biomedicine ; C-Reactive Protein - analysis ; Cancer Research ; Carcinoma, Pancreatic Ductal - blood ; Carcinoma, Pancreatic Ductal - immunology ; Carcinoma, Pancreatic Ductal - surgery ; Clinical Study ; Drug Resistance ; Epidemiology ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Humans ; Inflammation - complications ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Lymphatic system ; Male ; Medical prognosis ; Medical research ; Medical sciences ; Middle Aged ; Molecular Medicine ; Multivariate Analysis ; Oncology ; Pancreas ; Pancreatectomy ; Pancreatic Neoplasms - blood ; Pancreatic Neoplasms - immunology ; Pancreatic Neoplasms - surgery ; Prognosis ; Proteins ; Retrospective Studies ; Surgery ; Survival Analysis ; Treatment Outcome ; Tumors</subject><ispartof>British journal of cancer, 2005-01, Vol.92 (1), p.21-23</ispartof><rights>The Author(s) 2005</rights><rights>2005 INIST-CNRS</rights><rights>Copyright Nature Publishing Group Jan 17, 2005</rights><rights>Copyright © 2005 Cancer Research UK 2005 Cancer Research UK</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c551t-2aa93416a1e9b309e13a5623dad161d7487fc623b4fde930756d822ea33a5403</citedby><cites>FETCH-LOGICAL-c551t-2aa93416a1e9b309e13a5623dad161d7487fc623b4fde930756d822ea33a5403</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361749/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361749/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,41464,42533,51294,53766,53768</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16480172$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15597096$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jamieson, N B</creatorcontrib><creatorcontrib>Glen, P</creatorcontrib><creatorcontrib>McMillan, D C</creatorcontrib><creatorcontrib>McKay, C J</creatorcontrib><creatorcontrib>Foulis, A K</creatorcontrib><creatorcontrib>Carter, R</creatorcontrib><creatorcontrib>Imrie, C W</creatorcontrib><title>Systemic inflammatory response predicts outcome in patients undergoing resection for ductal adenocarcinoma head of pancreas</title><title>British journal of cancer</title><addtitle>Br J Cancer</addtitle><addtitle>Br J Cancer</addtitle><description>The aim of the present study was to examine the relationship between the clinicopathological status, the pre- and postoperative systemic inflammatory response and survival in patients undergoing potentially curative resection for ductal adenocarcinoma of the head of the pancreas. Patients (
n
=65) who underwent resection of ductal adenocarcinoma of the head of pancreas between 1993 and 2001, and had pre- and postoperative measurements of C-reactive protein, were included in the study. The majority of patients had stage III disease (International Union Against Cancer Criteria, IUCC), positive circumferential margin involvement (R
1
), tumour size greater than 25 mm with perineural and lymph node invasion and died within the follow-up period. On multivariate analysis, tumour size (hazard ratio (HR) 2.10, 95% confidence interval (CI) 1.20–3.68,
P
=0.009), vascular invasion (HR 2.58, 95% CI 1.48–4.50,
P
<0.001) and postoperative C-reactive protein (HR 2.00, 95% CI 1.14–3.52,
P
=0.015) retained independent significance. Those patients with a postoperative C-reactive protein ⩽10 mg l
−1
had a median survival of 21.5 months compared with 8.4 months in those patients with a C-reactive protein >10 mg l
−1
(
P
<0.001). The results of the present study indicate that, in patients who have undergone potentially curative resection for ductal adenocarcinoma of the head of pancreas, the presence of a systemic inflammatory response predicts poor outcome.</description><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>C-Reactive Protein - analysis</subject><subject>Cancer Research</subject><subject>Carcinoma, Pancreatic Ductal - blood</subject><subject>Carcinoma, Pancreatic Ductal - immunology</subject><subject>Carcinoma, Pancreatic Ductal - surgery</subject><subject>Clinical Study</subject><subject>Drug Resistance</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Humans</subject><subject>Inflammation - complications</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Lymphatic system</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Molecular Medicine</subject><subject>Multivariate Analysis</subject><subject>Oncology</subject><subject>Pancreas</subject><subject>Pancreatectomy</subject><subject>Pancreatic Neoplasms - blood</subject><subject>Pancreatic Neoplasms - immunology</subject><subject>Pancreatic Neoplasms - surgery</subject><subject>Prognosis</subject><subject>Proteins</subject><subject>Retrospective Studies</subject><subject>Surgery</subject><subject>Survival Analysis</subject><subject>Treatment Outcome</subject><subject>Tumors</subject><issn>0007-0920</issn><issn>1532-1827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kc2LFDEQxYMo7rh69SiN4N56Nh_dSeciyOKqsODBvYeapHo2TXcyJt3C4D9vlmkcFTyFSv1e1UseIa8Z3TIquus8bHeD3UpJuaDtE7JhreA167h6SjaUUlVTzekFeZHzUEpNO_WcXLC21YpquSE_vx3zjJO3lQ_9CNMEc0zHKmE-xJCxOiR03s65ists44QFqw4wewzlbgkO0z76sH8UoJ19DFUfU-UWO8NYgcMQLSTrQ5ygekBwVeyLPtiEkF-SZz2MGV-t5yW5v_14f_O5vvv66cvNh7vati2baw6gRcMkMNQ7QTUyAa3kwoFjkjnVdKq3pd41vUMtqGql6zhHEIVrqLgk709jD8tuQmeL9QSjOSQ_QTqaCN783Qn-wezjD8OFZKrRZcDVOiDF7wvm2Uw-WxxHCBiXbKRqmKZKFvDtP-AQlxTK2wznWneUc1ag7QmyKeacsP_thFHzmKnJgymZmjXTInjzp_8zvoZYgHcrANnC2Kfyvz6fOdl0lCleuOsTl0sr7DGd7f1n9S-jzb3y</recordid><startdate>20050117</startdate><enddate>20050117</enddate><creator>Jamieson, N B</creator><creator>Glen, P</creator><creator>McMillan, D C</creator><creator>McKay, C J</creator><creator>Foulis, A K</creator><creator>Carter, R</creator><creator>Imrie, C W</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20050117</creationdate><title>Systemic inflammatory response predicts outcome in patients undergoing resection for ductal adenocarcinoma head of pancreas</title><author>Jamieson, N B ; Glen, P ; McMillan, D C ; McKay, C J ; Foulis, A K ; Carter, R ; Imrie, C W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c551t-2aa93416a1e9b309e13a5623dad161d7487fc623b4fde930756d822ea33a5403</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>C-Reactive Protein - analysis</topic><topic>Cancer Research</topic><topic>Carcinoma, Pancreatic Ductal - blood</topic><topic>Carcinoma, Pancreatic Ductal - immunology</topic><topic>Carcinoma, Pancreatic Ductal - surgery</topic><topic>Clinical Study</topic><topic>Drug Resistance</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Humans</topic><topic>Inflammation - complications</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>Lymphatic system</topic><topic>Male</topic><topic>Medical prognosis</topic><topic>Medical research</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Molecular Medicine</topic><topic>Multivariate Analysis</topic><topic>Oncology</topic><topic>Pancreas</topic><topic>Pancreatectomy</topic><topic>Pancreatic Neoplasms - blood</topic><topic>Pancreatic Neoplasms - immunology</topic><topic>Pancreatic Neoplasms - surgery</topic><topic>Prognosis</topic><topic>Proteins</topic><topic>Retrospective Studies</topic><topic>Surgery</topic><topic>Survival Analysis</topic><topic>Treatment Outcome</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jamieson, N B</creatorcontrib><creatorcontrib>Glen, P</creatorcontrib><creatorcontrib>McMillan, D C</creatorcontrib><creatorcontrib>McKay, C J</creatorcontrib><creatorcontrib>Foulis, A K</creatorcontrib><creatorcontrib>Carter, R</creatorcontrib><creatorcontrib>Imrie, C W</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jamieson, N B</au><au>Glen, P</au><au>McMillan, D C</au><au>McKay, C J</au><au>Foulis, A K</au><au>Carter, R</au><au>Imrie, C W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Systemic inflammatory response predicts outcome in patients undergoing resection for ductal adenocarcinoma head of pancreas</atitle><jtitle>British journal of cancer</jtitle><stitle>Br J Cancer</stitle><addtitle>Br J Cancer</addtitle><date>2005-01-17</date><risdate>2005</risdate><volume>92</volume><issue>1</issue><spage>21</spage><epage>23</epage><pages>21-23</pages><issn>0007-0920</issn><eissn>1532-1827</eissn><coden>BJCAAI</coden><abstract>The aim of the present study was to examine the relationship between the clinicopathological status, the pre- and postoperative systemic inflammatory response and survival in patients undergoing potentially curative resection for ductal adenocarcinoma of the head of the pancreas. Patients (
n
=65) who underwent resection of ductal adenocarcinoma of the head of pancreas between 1993 and 2001, and had pre- and postoperative measurements of C-reactive protein, were included in the study. The majority of patients had stage III disease (International Union Against Cancer Criteria, IUCC), positive circumferential margin involvement (R
1
), tumour size greater than 25 mm with perineural and lymph node invasion and died within the follow-up period. On multivariate analysis, tumour size (hazard ratio (HR) 2.10, 95% confidence interval (CI) 1.20–3.68,
P
=0.009), vascular invasion (HR 2.58, 95% CI 1.48–4.50,
P
<0.001) and postoperative C-reactive protein (HR 2.00, 95% CI 1.14–3.52,
P
=0.015) retained independent significance. Those patients with a postoperative C-reactive protein ⩽10 mg l
−1
had a median survival of 21.5 months compared with 8.4 months in those patients with a C-reactive protein >10 mg l
−1
(
P
<0.001). The results of the present study indicate that, in patients who have undergone potentially curative resection for ductal adenocarcinoma of the head of pancreas, the presence of a systemic inflammatory response predicts poor outcome.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>15597096</pmid><doi>10.1038/sj.bjc.6602305</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
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| ispartof | British journal of cancer, 2005-01, Vol.92 (1), p.21-23 |
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| language | eng |
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| source | MEDLINE; SpringerLink Journals; Nature; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Aged Biological and medical sciences Biomedical and Life Sciences Biomedicine C-Reactive Protein - analysis Cancer Research Carcinoma, Pancreatic Ductal - blood Carcinoma, Pancreatic Ductal - immunology Carcinoma, Pancreatic Ductal - surgery Clinical Study Drug Resistance Epidemiology Female Gastroenterology. Liver. Pancreas. Abdomen Humans Inflammation - complications Liver. Biliary tract. Portal circulation. Exocrine pancreas Lymphatic system Male Medical prognosis Medical research Medical sciences Middle Aged Molecular Medicine Multivariate Analysis Oncology Pancreas Pancreatectomy Pancreatic Neoplasms - blood Pancreatic Neoplasms - immunology Pancreatic Neoplasms - surgery Prognosis Proteins Retrospective Studies Surgery Survival Analysis Treatment Outcome Tumors |
| title | Systemic inflammatory response predicts outcome in patients undergoing resection for ductal adenocarcinoma head of pancreas |
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