A dose-escalation study of indisulam in combination with capecitabine (Xeloda) in patients with solid tumours

This dose escalation study was designed to determine the recommended dose of the multi-targeted cell cycle inhibitor indisulam in combination with capecitabine in patients with solid tumours and to evaluate the pharmacokinetics of the combination. Thirty-five patients were treated with indisulam on...

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Veröffentlicht in:	British journal of cancer 2008-04, Vol.98 (8), p.1320-1326
Hauptverfasser:	Siegel-Lakhai, W S, Zandvliet, A S, Huitema, A D R, Tibben, M M, Milano, G, Girre, V, Diéras, V, King, A, Richmond, E, Wanders, J, Beijnen, J H, Schellens, J H M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antineoplastic Combined Chemotherapy Protocols - therapeutic use Aryl Hydrocarbon Hydroxylases - antagonists & inhibitors Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer Research Cancer therapies Capecitabine Cell cycle Chemotherapy Clinical Study Cyclin-dependent kinases Cytochrome P-450 CYP2C9 Deoxycytidine - administration & dosage Deoxycytidine - adverse effects Deoxycytidine - analogs & derivatives Deoxycytidine - blood Drug Administration Schedule Drug dosages Drug Resistance Epidemiology Female Fluorouracil - administration & dosage Fluorouracil - adverse effects Fluorouracil - analogs & derivatives Fluorouracil - blood Humans Kinases Male Medical research Medical sciences Middle Aged Molecular Medicine Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Oncology Pharmacokinetics Sulfonamides - administration & dosage Sulfonamides - adverse effects Sulfonamides - blood Toxicity Tumors
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