Meta-analysis of cancer incidence in children born after assisted reproductive technologies

A meta-analysis was performed on 11 cohort studies of Assisted Reproductive Technologies (ART) and subsequent childhood cancer, published up to February 2005, which reported comparable, nonoverlapping data, and then restricted to eight studies which presented a similar research design. The overall S...

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Veröffentlicht in:British journal of cancer 2005-10, Vol.93 (9), p.1053-1056
Hauptverfasser: Raimondi, S, Pedotti, P, Taioli, E
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Pedotti, P
Taioli, E
description A meta-analysis was performed on 11 cohort studies of Assisted Reproductive Technologies (ART) and subsequent childhood cancer, published up to February 2005, which reported comparable, nonoverlapping data, and then restricted to eight studies which presented a similar research design. The overall Standardised Incidence Ratio was 1.33 (95% CI 0.62–2.85), and 0.77 (95% CI 0.41–1.42) when the analysis was restricted to eight studies. No evidence of publication bias was observed for the overall analysis. The data are consistent with a lack of increase in risk of childhood cancer, though the amount of data on ART and cancer is still limited; larger multicentric studies as well as a pooled analysis on the available data are warranted.
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subjects Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Cancer Research
Child
Cohort Studies
Drug Resistance
Epidemiology
Female
Fertility Agents, Female - administration & dosage
Humans
Incidence
Infertility, Female - therapy
Italy - epidemiology
Medical sciences
Molecular Medicine
Neoplasms - epidemiology
Oncology
Reproductive Techniques, Assisted - statistics & numerical data
Tumors
title Meta-analysis of cancer incidence in children born after assisted reproductive technologies
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