Meta-analysis of cancer incidence in children born after assisted reproductive technologies
A meta-analysis was performed on 11 cohort studies of Assisted Reproductive Technologies (ART) and subsequent childhood cancer, published up to February 2005, which reported comparable, nonoverlapping data, and then restricted to eight studies which presented a similar research design. The overall S...
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Veröffentlicht in: | British journal of cancer 2005-10, Vol.93 (9), p.1053-1056 |
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description | A meta-analysis was performed on 11 cohort studies of Assisted Reproductive Technologies (ART) and subsequent childhood cancer, published up to February 2005, which reported comparable, nonoverlapping data, and then restricted to eight studies which presented a similar research design. The overall Standardised Incidence Ratio was 1.33 (95% CI 0.62–2.85), and 0.77 (95% CI 0.41–1.42) when the analysis was restricted to eight studies. No evidence of publication bias was observed for the overall analysis. The data are consistent with a lack of increase in risk of childhood cancer, though the amount of data on ART and cancer is still limited; larger multicentric studies as well as a pooled analysis on the available data are warranted. |
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The overall Standardised Incidence Ratio was 1.33 (95% CI 0.62–2.85), and 0.77 (95% CI 0.41–1.42) when the analysis was restricted to eight studies. No evidence of publication bias was observed for the overall analysis. The data are consistent with a lack of increase in risk of childhood cancer, though the amount of data on ART and cancer is still limited; larger multicentric studies as well as a pooled analysis on the available data are warranted.</description><identifier>ISSN: 0007-0920</identifier><identifier>EISSN: 1532-1827</identifier><identifier>DOI: 10.1038/sj.bjc.6602838</identifier><identifier>PMID: 16234814</identifier><identifier>CODEN: BJCAAI</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Biological and medical sciences ; Biomedical and Life Sciences ; Biomedicine ; Cancer Research ; Child ; Cohort Studies ; Drug Resistance ; Epidemiology ; Female ; Fertility Agents, Female - administration & dosage ; Humans ; Incidence ; Infertility, Female - therapy ; Italy - epidemiology ; Medical sciences ; Molecular Medicine ; Neoplasms - epidemiology ; Oncology ; Reproductive Techniques, Assisted - statistics & numerical data ; Tumors</subject><ispartof>British journal of cancer, 2005-10, Vol.93 (9), p.1053-1056</ispartof><rights>The Author(s) 2005</rights><rights>2005 INIST-CNRS</rights><rights>Copyright Nature Publishing Group Oct 31, 2005</rights><rights>Copyright © 2005 Cancer Research UK 2005 Cancer Research UK</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c530t-57f2a31512b7af2c33a31e0ee5b1b68250a76be3afaf8e0932dd72e2b86add233</citedby><cites>FETCH-LOGICAL-c530t-57f2a31512b7af2c33a31e0ee5b1b68250a76be3afaf8e0932dd72e2b86add233</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361681/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361681/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,41464,42533,51294,53766,53768</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17218232$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16234814$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Raimondi, S</creatorcontrib><creatorcontrib>Pedotti, P</creatorcontrib><creatorcontrib>Taioli, E</creatorcontrib><title>Meta-analysis of cancer incidence in children born after assisted reproductive technologies</title><title>British journal of cancer</title><addtitle>Br J Cancer</addtitle><addtitle>Br J Cancer</addtitle><description>A meta-analysis was performed on 11 cohort studies of Assisted Reproductive Technologies (ART) and subsequent childhood cancer, published up to February 2005, which reported comparable, nonoverlapping data, and then restricted to eight studies which presented a similar research design. The overall Standardised Incidence Ratio was 1.33 (95% CI 0.62–2.85), and 0.77 (95% CI 0.41–1.42) when the analysis was restricted to eight studies. No evidence of publication bias was observed for the overall analysis. The data are consistent with a lack of increase in risk of childhood cancer, though the amount of data on ART and cancer is still limited; larger multicentric studies as well as a pooled analysis on the available data are warranted.</description><subject>Biological and medical sciences</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer Research</subject><subject>Child</subject><subject>Cohort Studies</subject><subject>Drug Resistance</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Fertility Agents, Female - administration & dosage</subject><subject>Humans</subject><subject>Incidence</subject><subject>Infertility, Female - therapy</subject><subject>Italy - epidemiology</subject><subject>Medical sciences</subject><subject>Molecular Medicine</subject><subject>Neoplasms - epidemiology</subject><subject>Oncology</subject><subject>Reproductive Techniques, Assisted - statistics & numerical data</subject><subject>Tumors</subject><issn>0007-0920</issn><issn>1532-1827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kc2LFDEQxYMo7uzq1aM0gt56Nh_bSeYiLIuuwooXPXkI1UllJk1PMibdC_vfm2UaRwVPqaJ-9fKoR8grRteMCn1ZhnU_2LWUlGuhn5AV6wRvmebqKVlRSlVLN5yekfNShtpuqFbPyRmTXFxpdrUiP77gBC1EGB9KKE3yjYVoMTch2uCwlrVq7C6MLmNs-pRjA36qAJS6MKFrMh5ycrOdwj02E9pdTGPaBiwvyDMPY8GXy3tBvn_88O3mU3v39fbzzfVdaztBp7ZTnoNgHeO9As-tELVDitj1rJeadxSU7FGAB6-RbgR3TnHkvZbgHBfigrw_6h7mfo_OYpwyjOaQwx7yg0kQzN-TGHZmm-4NF5JJzarAu0Ugp58zlsnsQ7E4jhAxzcVIrQSlXFXwzT_gkOZcj1eqVj0v1fLRzvoI2ZxKyeh_O2HUPIZmymBqaGYJrS68_tP_CV9SqsDbBYBiYfS5RhTKiVO8Bi545S6PXKmjuMV8svefr38BMf-ySg</recordid><startdate>20051031</startdate><enddate>20051031</enddate><creator>Raimondi, S</creator><creator>Pedotti, P</creator><creator>Taioli, E</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20051031</creationdate><title>Meta-analysis of cancer incidence in children born after assisted reproductive technologies</title><author>Raimondi, S ; 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subjects | Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer Research Child Cohort Studies Drug Resistance Epidemiology Female Fertility Agents, Female - administration & dosage Humans Incidence Infertility, Female - therapy Italy - epidemiology Medical sciences Molecular Medicine Neoplasms - epidemiology Oncology Reproductive Techniques, Assisted - statistics & numerical data Tumors |
title | Meta-analysis of cancer incidence in children born after assisted reproductive technologies |
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