Expression of the 5T4 oncofoetal antigen in renal cell carcinoma: a potential target for T-cell-based immunotherapy

The 5T4 oncofoetal antigen is a heavily glycosylated cell surface protein found on human placental trophoblast and on diverse types of human cancer but is not expressed at significant levels on adult human tissues in health. It therefore satisfies the criteria for a tumour-associated antigen and is...

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Veröffentlicht in:	British journal of cancer 2005-09, Vol.93 (6), p.670-677
Hauptverfasser:	Griffiths, R W, Gilham, D E, Dangoor, A, Ramani, V, Clarke, N W, Stern, P L, Hawkins, R E
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma, Clear Cell - metabolism Adult Aged Antibodies, Monoclonal Antigens Antigens, Neoplasm - immunology Apoptosis Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer Research Cancer therapies Carcinoma, Papillary - metabolism Carcinoma, Renal Cell - metabolism Chromium - metabolism Cytotoxicity Drug Resistance Enzyme-Linked Immunosorbent Assay Epidemiology Female Flow Cytometry Glycoproteins Humans Immunotherapy Interferon-gamma - metabolism Kidney cancer Kidney Neoplasms - metabolism Kidneys Male Medical research Medical sciences Membrane Glycoproteins - immunology Membrane Glycoproteins - metabolism Metastasis Middle Aged Molecular Medicine Monoclonal antibodies Nephrology. Urinary tract diseases Oncology Proteins T-Lymphocytes - immunology Translational Therapeutics Tumors Tumors of the urinary system
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