Squamous cell cancers contain a side population of stem-like cells that are made chemosensitive by ABC transporter blockade

Cancers are a heterogeneous mix of cells, some of which exhibit cancer stem cell-like characteristics including ATP-dependent drug efflux and elevated tumorigenic potential. To determine whether aerodigestive squamous cell carcinomas (SCCs) contain a subpopulation of cancer stem cell-like cells, we...

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Veröffentlicht in:	British journal of cancer 2008-01, Vol.98 (2), p.380-387
Hauptverfasser:	Loebinger, M R, Giangreco, A, Groot, K R, Prichard, L, Allen, K, Simpson, C, Bazley, L, Navani, N, Tibrewal, S, Davies, D, Janes, S M
Format:	Artikel
Sprache:	eng
Schlagworte:	ABC transporters Animals Antineoplastic Agents - pharmacology ATP Binding Cassette Transporter, Subfamily G, Member 2 ATP-Binding Cassette Transporters - antagonists & inhibitors ATP-Binding Cassette Transporters - genetics ATP-Binding Cassette Transporters - metabolism Biological and medical sciences Biomarkers, Tumor - metabolism Biomedical and Life Sciences Biomedicine Cancer Research Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - pathology Cell Count Cell Line, Tumor Cell Proliferation Cell Separation Drug Resistance Drug Resistance, Neoplasm - drug effects Drug Resistance, Neoplasm - genetics Epidemiology Genotype & phenotype Humans Male Medical research Medical sciences Mice Mice, Inbred NOD Mice, SCID Molecular Medicine Multidrug Resistance-Associated Proteins - genetics Multidrug Resistance-Associated Proteins - metabolism Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Neoplastic Stem Cells - drug effects Neoplastic Stem Cells - metabolism Neoplastic Stem Cells - pathology Neuroblastoma Oncology Pollutants Stem cells Translational Therapeutics Tumors Verapamil - pharmacology Xenograft Model Antitumor Assays
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