hTERT phosphorylation by PKC is essential for telomerase holoprotein integrity and enzyme activity in head neck cancer cells

Telomerase activity is suppressed in normal somatic tissues but is activated in most cancer cells. We have previously found that all six telomerase subunit proteins, including hTERT and hsp90 are needed for full enzyme activity. Telomerase activity has been reported to be upregulated by protein kina...

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Veröffentlicht in:	British journal of cancer 2006-03, Vol.94 (6), p.870-878
Hauptverfasser:	Chang, J T, Lu, Y-C, Chen, Y-J, Tseng, C-P, Chen, Y-L, Fang, C-W, Cheng, A-J
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer Research Cell Transformation, Neoplastic DNA-Binding Proteins - metabolism Drug Resistance Enzyme Activation Enzymes Epidemiology Head & neck cancer Head and Neck Neoplasms - enzymology Head and Neck Neoplasms - genetics Humans Kinases Medical research Medical sciences Molecular Diagnostics Molecular Medicine Oncology Otorhinolaryngology (head neck, general aspects and miscellaneous) Otorhinolaryngology. Stomatology Phosphorylation Protein Kinase C - metabolism Proteins RNA Interference Telomerase Telomerase - metabolism Tumor Cells, Cultured Tumors Up-Regulation
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