Concurrent infiltration by CD8+ T cells and CD4+ T cells is a favourable prognostic factor in non-small-cell lung carcinoma
The purpose of this study was to clarify the relationship between the number of tumour-infiltrating T lymphocytes and the clinicopathological features and clinical outcome in patients with non-small-cell lung cancer (NSCLC). Tissue specimens from 109 patients who underwent surgical resection for NSC...
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| Veröffentlicht in: | British journal of cancer 2006-01, Vol.94 (2), p.275-280 |
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| creator | Hiraoka, K Miyamoto, M Cho, Y Suzuoki, M Oshikiri, T Nakakubo, Y Itoh, T Ohbuchi, T Kondo, S Katoh, H |
| description | The purpose of this study was to clarify the relationship between the number of tumour-infiltrating T lymphocytes and the clinicopathological features and clinical outcome in patients with non-small-cell lung cancer (NSCLC). Tissue specimens from 109 patients who underwent surgical resection for NSCLC were immunohistochemically analysed for CD4 and CD8 expression. Patients were classified into two groups according to whether their tumours exhibited a ‘high’ or ‘low’ level of CD8
+
or CD4
+
lymphocyte infiltration. Although the level of infiltration by CD8
+
T cells alone had no prognostic significance, the survival rate for patients with both ‘high’ CD8
+
and ‘high’ CD4
+
T-cell infiltration was significantly higher than that for the other groups (log-rank test,
P
=0.006). Multivariate analysis indicated that concomitant high CD8
+
and high CD4
+
T-cell infiltration was an independent favourable prognostic factor (
P
=0.0092). In conclusion, the presence of high levels of both CD8
+
T cells and CD4
+
T cells is a significant indicator of a better prognosis for patients with NSCLC, and cooperation between these cell populations may allow a significantly more potent antitumour response than either population alone. |
| doi_str_mv | 10.1038/sj.bjc.6602934 |
| format | Article |
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+
or CD4
+
lymphocyte infiltration. Although the level of infiltration by CD8
+
T cells alone had no prognostic significance, the survival rate for patients with both ‘high’ CD8
+
and ‘high’ CD4
+
T-cell infiltration was significantly higher than that for the other groups (log-rank test,
P
=0.006). Multivariate analysis indicated that concomitant high CD8
+
and high CD4
+
T-cell infiltration was an independent favourable prognostic factor (
P
=0.0092). In conclusion, the presence of high levels of both CD8
+
T cells and CD4
+
T cells is a significant indicator of a better prognosis for patients with NSCLC, and cooperation between these cell populations may allow a significantly more potent antitumour response than either population alone.</description><identifier>ISSN: 0007-0920</identifier><identifier>EISSN: 1532-1827</identifier><identifier>DOI: 10.1038/sj.bjc.6602934</identifier><identifier>PMID: 16421594</identifier><identifier>CODEN: BJCAAI</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Biomedical and Life Sciences ; Biomedicine ; Cancer Research ; Carcinoma, Non-Small-Cell Lung - immunology ; Carcinoma, Non-Small-Cell Lung - mortality ; CD4-Positive T-Lymphocytes - immunology ; CD8-Positive T-Lymphocytes - immunology ; Drug Resistance ; Epidemiology ; Female ; Hospitals ; Humans ; Immunohistochemistry ; Lung cancer ; Lung Neoplasms - immunology ; Lung Neoplasms - mortality ; Lymphocytes ; Male ; Medical prognosis ; Medical research ; Medical sciences ; Medicine ; Middle Aged ; Molecular Diagnostics ; Molecular Medicine ; Oncology ; Patients ; Pneumology ; Prognosis ; Survival Analysis ; Survival Rate ; Thoracic surgery ; Tumors ; Tumors of the respiratory system and mediastinum</subject><ispartof>British journal of cancer, 2006-01, Vol.94 (2), p.275-280</ispartof><rights>The Author(s) 2006</rights><rights>2006 INIST-CNRS</rights><rights>Copyright Nature Publishing Group Jan 30, 2006</rights><rights>Copyright © 2006 Cancer Research UK 2006 Cancer Research UK</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c485t-2f3ff12290394185100c85ad1141996be10332eb7c3ce09916ee9fb2f2fa9e1b3</citedby><cites>FETCH-LOGICAL-c485t-2f3ff12290394185100c85ad1141996be10332eb7c3ce09916ee9fb2f2fa9e1b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361103/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361103/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,41464,42533,51294,53766,53768</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17666328$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16421594$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hiraoka, K</creatorcontrib><creatorcontrib>Miyamoto, M</creatorcontrib><creatorcontrib>Cho, Y</creatorcontrib><creatorcontrib>Suzuoki, M</creatorcontrib><creatorcontrib>Oshikiri, T</creatorcontrib><creatorcontrib>Nakakubo, Y</creatorcontrib><creatorcontrib>Itoh, T</creatorcontrib><creatorcontrib>Ohbuchi, T</creatorcontrib><creatorcontrib>Kondo, S</creatorcontrib><creatorcontrib>Katoh, H</creatorcontrib><title>Concurrent infiltration by CD8+ T cells and CD4+ T cells is a favourable prognostic factor in non-small-cell lung carcinoma</title><title>British journal of cancer</title><addtitle>Br J Cancer</addtitle><addtitle>Br J Cancer</addtitle><description>The purpose of this study was to clarify the relationship between the number of tumour-infiltrating T lymphocytes and the clinicopathological features and clinical outcome in patients with non-small-cell lung cancer (NSCLC). Tissue specimens from 109 patients who underwent surgical resection for NSCLC were immunohistochemically analysed for CD4 and CD8 expression. Patients were classified into two groups according to whether their tumours exhibited a ‘high’ or ‘low’ level of CD8
+
or CD4
+
lymphocyte infiltration. Although the level of infiltration by CD8
+
T cells alone had no prognostic significance, the survival rate for patients with both ‘high’ CD8
+
and ‘high’ CD4
+
T-cell infiltration was significantly higher than that for the other groups (log-rank test,
P
=0.006). Multivariate analysis indicated that concomitant high CD8
+
and high CD4
+
T-cell infiltration was an independent favourable prognostic factor (
P
=0.0092). In conclusion, the presence of high levels of both CD8
+
T cells and CD4
+
T cells is a significant indicator of a better prognosis for patients with NSCLC, and cooperation between these cell populations may allow a significantly more potent antitumour response than either population alone.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer Research</subject><subject>Carcinoma, Non-Small-Cell Lung - immunology</subject><subject>Carcinoma, Non-Small-Cell Lung - mortality</subject><subject>CD4-Positive T-Lymphocytes - immunology</subject><subject>CD8-Positive T-Lymphocytes - immunology</subject><subject>Drug Resistance</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Lung cancer</subject><subject>Lung Neoplasms - immunology</subject><subject>Lung Neoplasms - mortality</subject><subject>Lymphocytes</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Middle Aged</subject><subject>Molecular Diagnostics</subject><subject>Molecular Medicine</subject><subject>Oncology</subject><subject>Patients</subject><subject>Pneumology</subject><subject>Prognosis</subject><subject>Survival Analysis</subject><subject>Survival Rate</subject><subject>Thoracic surgery</subject><subject>Tumors</subject><subject>Tumors of the respiratory system and mediastinum</subject><issn>0007-0920</issn><issn>1532-1827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kc2LFDEQxYMo7jh69ShB0Iv0bD66052LIOPXwsJe1nNIZ5IxTToZk-6FxX_eGqZxdGFPIa9-eamqh9BrSjaU8O6yDJt-MBshCJO8foJWtOGsoh1rn6IVIaStiGTkAr0oZYCrJF37HF1QUTPayHqFfm9TNHPONk7YR-fDlPXkU8T9Pd5-7j7gW2xsCAXruAOhPgseNOz0XZqz7oPFh5z2MZXJG1DNlDL44ZhiVUYdQnV8hMMc99jobHxMo36Jnjkdin21nGv04-uX2-336vrm29X203Vl6q6ZKua4c5QxSbisaddQQkzX6B2lNZVS9BYWwZntW8ONJVJSYa10PXPMaWlpz9fo48n3MPej3RmYNeugDtmPOt-rpL36vxL9T7VPd4pxQY_ma_R-Mcjp12zLpEZfjgPpaNNcVEtayggTAL59AA6wngjDgResn7Zgt0abE2RyKiVb97cTStQxVFUGBaGqJVR48Obf_s_4kiIA7xZAF6ODyzoaX85cK4TgrAPu8sQVKMW9zef2Hvn6D4NTus0</recordid><startdate>20060130</startdate><enddate>20060130</enddate><creator>Hiraoka, K</creator><creator>Miyamoto, M</creator><creator>Cho, Y</creator><creator>Suzuoki, M</creator><creator>Oshikiri, T</creator><creator>Nakakubo, Y</creator><creator>Itoh, T</creator><creator>Ohbuchi, T</creator><creator>Kondo, S</creator><creator>Katoh, H</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20060130</creationdate><title>Concurrent infiltration by CD8+ T cells and CD4+ T cells is a favourable prognostic factor in non-small-cell lung carcinoma</title><author>Hiraoka, K ; Miyamoto, M ; Cho, Y ; Suzuoki, M ; Oshikiri, T ; Nakakubo, Y ; Itoh, T ; Ohbuchi, T ; Kondo, S ; Katoh, H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c485t-2f3ff12290394185100c85ad1141996be10332eb7c3ce09916ee9fb2f2fa9e1b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cancer Research</topic><topic>Carcinoma, Non-Small-Cell Lung - immunology</topic><topic>Carcinoma, Non-Small-Cell Lung - mortality</topic><topic>CD4-Positive T-Lymphocytes - immunology</topic><topic>CD8-Positive T-Lymphocytes - immunology</topic><topic>Drug Resistance</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Lung cancer</topic><topic>Lung Neoplasms - immunology</topic><topic>Lung Neoplasms - mortality</topic><topic>Lymphocytes</topic><topic>Male</topic><topic>Medical prognosis</topic><topic>Medical research</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Middle Aged</topic><topic>Molecular Diagnostics</topic><topic>Molecular Medicine</topic><topic>Oncology</topic><topic>Patients</topic><topic>Pneumology</topic><topic>Prognosis</topic><topic>Survival Analysis</topic><topic>Survival Rate</topic><topic>Thoracic surgery</topic><topic>Tumors</topic><topic>Tumors of the respiratory system and mediastinum</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hiraoka, K</creatorcontrib><creatorcontrib>Miyamoto, M</creatorcontrib><creatorcontrib>Cho, Y</creatorcontrib><creatorcontrib>Suzuoki, M</creatorcontrib><creatorcontrib>Oshikiri, T</creatorcontrib><creatorcontrib>Nakakubo, Y</creatorcontrib><creatorcontrib>Itoh, T</creatorcontrib><creatorcontrib>Ohbuchi, T</creatorcontrib><creatorcontrib>Kondo, S</creatorcontrib><creatorcontrib>Katoh, H</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hiraoka, K</au><au>Miyamoto, M</au><au>Cho, Y</au><au>Suzuoki, M</au><au>Oshikiri, T</au><au>Nakakubo, Y</au><au>Itoh, T</au><au>Ohbuchi, T</au><au>Kondo, S</au><au>Katoh, H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Concurrent infiltration by CD8+ T cells and CD4+ T cells is a favourable prognostic factor in non-small-cell lung carcinoma</atitle><jtitle>British journal of cancer</jtitle><stitle>Br J Cancer</stitle><addtitle>Br J Cancer</addtitle><date>2006-01-30</date><risdate>2006</risdate><volume>94</volume><issue>2</issue><spage>275</spage><epage>280</epage><pages>275-280</pages><issn>0007-0920</issn><eissn>1532-1827</eissn><coden>BJCAAI</coden><abstract>The purpose of this study was to clarify the relationship between the number of tumour-infiltrating T lymphocytes and the clinicopathological features and clinical outcome in patients with non-small-cell lung cancer (NSCLC). Tissue specimens from 109 patients who underwent surgical resection for NSCLC were immunohistochemically analysed for CD4 and CD8 expression. Patients were classified into two groups according to whether their tumours exhibited a ‘high’ or ‘low’ level of CD8
+
or CD4
+
lymphocyte infiltration. Although the level of infiltration by CD8
+
T cells alone had no prognostic significance, the survival rate for patients with both ‘high’ CD8
+
and ‘high’ CD4
+
T-cell infiltration was significantly higher than that for the other groups (log-rank test,
P
=0.006). Multivariate analysis indicated that concomitant high CD8
+
and high CD4
+
T-cell infiltration was an independent favourable prognostic factor (
P
=0.0092). In conclusion, the presence of high levels of both CD8
+
T cells and CD4
+
T cells is a significant indicator of a better prognosis for patients with NSCLC, and cooperation between these cell populations may allow a significantly more potent antitumour response than either population alone.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>16421594</pmid><doi>10.1038/sj.bjc.6602934</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| issn | 0007-0920 1532-1827 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2361103 |
| source | MEDLINE; Nature; EZB-FREE-00999 freely available EZB journals; PubMed Central; SpringerNature Complete Journals |
| subjects | Adult Aged Aged, 80 and over Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer Research Carcinoma, Non-Small-Cell Lung - immunology Carcinoma, Non-Small-Cell Lung - mortality CD4-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - immunology Drug Resistance Epidemiology Female Hospitals Humans Immunohistochemistry Lung cancer Lung Neoplasms - immunology Lung Neoplasms - mortality Lymphocytes Male Medical prognosis Medical research Medical sciences Medicine Middle Aged Molecular Diagnostics Molecular Medicine Oncology Patients Pneumology Prognosis Survival Analysis Survival Rate Thoracic surgery Tumors Tumors of the respiratory system and mediastinum |
| title | Concurrent infiltration by CD8+ T cells and CD4+ T cells is a favourable prognostic factor in non-small-cell lung carcinoma |
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