Significance of nerve growth factor overexpression and its autocrine loop in oesophageal squamous cell carcinoma

Nerve growth factor (NGF) is overexpressed not only in nervous system, but also in several types of cancers. However, the role of NGF in oesophageal squamous cell carcinoma (OESCC) remains unclear. Here, we show the first evidence of NGF-TrkA autocrine loop and clinical significance of NGF overexpre...

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Veröffentlicht in:	British journal of cancer 2006-08, Vol.95 (3), p.322-330
Hauptverfasser:	Tsunoda, S, Okumura, T, Ito, T, Mori, Y, Soma, T, Watanabe, G, Kaganoi, J, Itami, A, Sakai, Y, Shimada, Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Antibodies - pharmacology Autocrine Communication - drug effects Autocrine Communication - genetics Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer Research Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - pathology Carcinoma, Squamous Cell - surgery Cell Line, Tumor Cell Movement - drug effects Dose-Response Relationship, Drug Drug Resistance Epidemiology Esophageal cancer Esophageal Neoplasms - genetics Esophageal Neoplasms - pathology Esophageal Neoplasms - surgery Esophagus Female Gastroenterology. Liver. Pancreas. Abdomen Gene Expression Profiling Gene Expression Regulation, Neoplastic - drug effects Gene Expression Regulation, Neoplastic - genetics Growth factors Humans Kinases Lymphatic system Male Medical prognosis Medical research Medical sciences Metastasis Middle Aged Molecular Diagnostics Molecular Medicine Nerve Growth Factor - biosynthesis Nerve Growth Factor - drug effects Nerve Growth Factor - genetics Nervous system Oncology Receptor, trkA Receptors, Nerve Growth Factor - antagonists & inhibitors Receptors, Nerve Growth Factor - genetics Reverse Transcriptase Polymerase Chain Reaction RNA, Small Interfering - pharmacology Surgery Tumor Cells, Cultured Tumors
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