CD70 (TNFSF7) is expressed at high prevalence in renal cell carcinomas and is rapidly internalised on antibody binding

In order to identify potential markers of renal cancer, the plasma membrane protein content of renal cell carcinoma (RCC)-derived cell lines was annotated using a proteomics process. One unusual protein identified at high levels in A498 and 786-O cells was CD70 (TNFSF7), a type II transmembrane rece...

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Veröffentlicht in:	British journal of cancer 2006-08, Vol.95 (3), p.298-306
Hauptverfasser:	Adam, P J, Terrett, J A, Steers, G, Stockwin, L, Loader, J A, Fletcher, G C, Lu, L-S, Leach, B I, Mason, S, Stamps, A C, Boyd, R S, Pezzella, F, Gatter, K C, Harris, A L
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies - pharmacology Antigen-Antibody Reactions Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer Research Carcinoma, Renal Cell - drug therapy Carcinoma, Renal Cell - immunology Carcinoma, Renal Cell - pathology CD27 Ligand - genetics CD27 Ligand - immunology CD27 Ligand - metabolism Cell Line, Tumor Drug Resistance Epidemiology Gene Expression Profiling Gene Expression Regulation, Neoplastic - genetics Humans Immunohistochemistry Kidney Neoplasms - drug therapy Kidney Neoplasms - immunology Kidney Neoplasms - pathology Kidneys Medical sciences Molecular Diagnostics Molecular Medicine Nephrology. Urinary tract diseases Oncology Protein Binding Proteomics - methods Reverse Transcriptase Polymerase Chain Reaction Tumors Tumors of the urinary system
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