Fatty acid synthase: a novel target for antiglioma therapy

High levels of fatty acid synthase (FAS) expression have been observed in several cancers, including breast, prostate, colon and lung carcinoma, compared with their respective normal tissue. We present data that show high levels of FAS protein in human and rat glioma cell lines and human glioma tiss...

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Veröffentlicht in:	British journal of cancer 2006-10, Vol.95 (7), p.869-878
Hauptverfasser:	Zhao, W, Kridel, S, Thorburn, A, Kooshki, M, Little, J, Hebbar, S, Robbins, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Apoptosis - drug effects Apoptosis - physiology Astrocytes - drug effects Base Sequence Biological and medical sciences Biomedical and Life Sciences Biomedicine Blotting, Western Brain - enzymology Brain cancer Brain Neoplasms - drug therapy Brain Neoplasms - enzymology Brain research Breast cancer Cancer Research Cancer therapies Cell cycle Cell death Cell growth Cell Line, Tumor Cerulenin - pharmacology Collagen Type XI - drug effects Collagen Type XI - metabolism Colon Cytotoxicity Dose-Response Relationship, Drug Drug dosages Drug Resistance Enzyme Inhibitors - pharmacology Epidemiology Fatty Acid Synthases - drug effects Fatty Acid Synthases - genetics Fatty Acid Synthases - metabolism Fatty acids Flow Cytometry Glioma - drug therapy Glioma - enzymology Humans Medical research Medical sciences Molecular Medicine Molecular Sequence Data Neurology Oncology Prostate cancer Proto-Oncogene Proteins c-bcl-2 - metabolism Radiation Tolerance - drug effects Rats RNA, Small Interfering Thyroid gland Toxicity Transfection Translational Therapeutics Tumors Tumors of the nervous system. Phacomatoses
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