Increased Dickkopf-1 expression in breast cancer bone metastases

The aim of this study was to determine whether Dickkopf-1 (Dkk-1) expression in breast cancer was associated with bone metastases. We first analysed Dkk-1 expression by human breast cancer cell lines that induce osteolytic or osteoblastic lesions in animals. Dickkopf-1 levels were then measured in t...

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Veröffentlicht in:	British journal of cancer 2007-10, Vol.97 (7), p.964-970
Hauptverfasser:	Voorzanger-Rousselot, N, Goehrig, D, Journe, F, Doriath, V, Body, J J, Clézardin, P, Garnero, P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomedical and Life Sciences Biomedicine Blotting, Western Bone Neoplasms - metabolism Bone Neoplasms - secondary Bone Resorption Breast cancer Breast Neoplasms - metabolism Breast Neoplasms - pathology Cancer Research Drug Resistance Enzyme-Linked Immunosorbent Assay Epidemiology Female Humans Intercellular Signaling Peptides and Proteins - genetics Intercellular Signaling Peptides and Proteins - metabolism Mice Mice, Nude Molecular Diagnostics Molecular Medicine Oncology Osteolysis Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics RNA, Messenger - metabolism RNA, Neoplasm - genetics RNA, Neoplasm - metabolism Tumor Cells, Cultured
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