PLD1 is overexpressed in an ER-negative MCF-7 cell line variant and a subset of phospho-Akt-negative breast carcinomas

We have used a novel variant of the human oestrogen receptor (ER)-positive MCF-7 cell line, TMX2-28, as a model to study breast cancer. TMX2-28 cells show no detectable levels of mRNA or protein expression for the ER and express basal cytokeratins (CKs) 5, 14, and 17. cDNA microarray comparison betw...

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Veröffentlicht in:	British journal of cancer 2007-09, Vol.97 (6), p.809-817
Hauptverfasser:	Gozgit, J M, Pentecost, B T, Marconi, S A, Ricketts-Loriaux, R S J, Otis, C N, Arcaro, K F
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomedical and Life Sciences Biomedicine Blotting, Western Breast cancer Breast Neoplasms - enzymology Breast Neoplasms - metabolism Cancer Research Cell culture Cell growth Cell Line, Tumor DNA, Complementary - metabolism Drug Resistance Epidemiology Female Humans Immunohistochemistry Kinases Medical research Microarray Analysis Molecular Diagnostics Molecular Medicine Oncogene Protein v-akt - metabolism Oncology Phospholipase D - genetics Phospholipase D - metabolism Protein Kinases - metabolism Proteins Receptors, Estrogen - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - metabolism TOR Serine-Threonine Kinases Tumors Up-Regulation
Online-Zugang:	Volltext
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