The enhancement of chondrogenic differentiation of human mesenchymal stem cells by enzymatically regulated RGD functionalities

Abstract A thiol–acrylate photopolymerization was used to incorporate enzymatically cleavable peptide sequences into PEG hydrogels to induce chondrogenic differentiation of encapsulated human mesenchymal stem cells (hMSCs). An adhesive sequence, RGD, was designed with an MMP-13 specific cleavable li...

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Veröffentlicht in:	Biomaterials 2008-05, Vol.29 (15), p.2370-2377
Hauptverfasser:	Salinas, Chelsea N, Anseth, Kristi S
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced Basic Science Antigens, CD - metabolism Cell Adhesion - drug effects Cell Differentiation - drug effects Cell Survival - drug effects Chondrocytes - cytology Chondrocytes - metabolism Chondrogenesis Collagen Type II - metabolism Collagenase-3 Dentistry Endoglin Glycosaminoglycans - metabolism Human mesenchymal stem cells Humans Hydrogels - chemical synthesis Hydrogels - chemistry Integrin alpha5beta1 - metabolism Integrin alphaVbeta3 - metabolism Matrix Metalloproteinase 13 - chemistry Matrix Metalloproteinase 13 - metabolism Mesenchymal Stem Cells - cytology Mesenchymal Stem Cells - drug effects Mesenchymal Stem Cells - metabolism Molecular Structure Oligopeptides - administration & dosage Oligopeptides - chemistry Oligopeptides - pharmacology Peptides - chemistry Photochemistry Polyethylene Glycols - chemical synthesis Polyethylene Glycols - chemistry Receptors, Cell Surface - metabolism RGD Tissue Engineering - methods Tissue Scaffolds - chemistry
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