High-throughput sequence analysis of the tyrosine kinome in acute myeloid leukemia

To determine whether aberrantly activated tyrosine kinases other than FLT3 and c-KIT contribute to acute myeloid leukemia (AML) pathogenesis, we used high-throughput (HT) DNA sequence ana-lysis to screen exons encoding the activation loop and juxtamembrane domains of 85 tyrosine kinase genes in 188...

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Veröffentlicht in:	Blood 2008-05, Vol.111 (9), p.4788-4796
Hauptverfasser:	Loriaux, Marc M., Levine, Ross L., Tyner, Jeffrey W., Fröhling, Stefan, Scholl, Claudia, Stoffregen, Eric P., Wernig, Gerlinde, Erickson, Heidi, Eide, Christopher A., Berger, Roland, Bernard, Olivier A., Griffin, James D., Stone, Richard M., Lee, Benjamin, Meyerson, Matthew, Heinrich, Michael C., Deininger, Michael W., Gilliland, D. Gary, Druker, Brian J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence DNA Mutational Analysis fms-Like Tyrosine Kinase 3 Humans Leukemia, Myeloid, Acute - enzymology Leukemia, Myeloid, Acute - etiology Neoplasia Polymorphism, Single Nucleotide Protein-Tyrosine Kinases - genetics
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