Baclofen inhibits guinea pig magnocellular neurones via activation of an inwardly rectifying K+ conductance

The GABA B receptors GABA B -R1 and GABA B -R2 have been cloned in several mammalian species, and the functional receptor has been shown to exist as a heterodimeric complex. We have cloned guinea pig GABA B -R1 and GABA B -R2 receptor sequences and, using in situ hybridization and immunocytochemistr...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of physiology 2003-08, Vol.551 (1), p.295-308
Hauptverfasser:	Slugg, Robert M, Zheng, Shi-Xi, Fang, Yuan, Kelly, Martin J, Rønnekleiv, Oline K
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Baclofen - pharmacology Electrophysiology Female GABA Agonists - pharmacology GABA Antagonists - pharmacology GABA-B Receptor Antagonists Guinea Pigs Immunohistochemistry Male Neural Inhibition Neurons - cytology Neurons - drug effects Organophosphorus Compounds - pharmacology Original Paraventricular Hypothalamic Nucleus - cytology Paraventricular Hypothalamic Nucleus - drug effects Paraventricular Hypothalamic Nucleus - metabolism Patch-Clamp Techniques Potassium Channels, Inwardly Rectifying - drug effects Potassium Channels, Inwardly Rectifying - physiology Receptors, GABA-B - genetics RNA, Messenger - metabolism Supraoptic Nucleus - cytology Supraoptic Nucleus - drug effects Supraoptic Nucleus - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!