Cannabinoid1 receptor in the dorsal vagal complex modulates lower oesophageal sphincter relaxation in ferrets

Delta 9 -tetrahydrocannabinol (Î 9 -THC) is an effective anti-emetic; however, other potential gastrointestinal therapeutic effects of Î 9 -THC are less well-known. Here, we report a role of Î 9 -THC in a vago-vagal reflex that can result in gastro-oesophageal reflux, that is, gastric distension-...

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Veröffentlicht in:	The Journal of physiology 2003-07, Vol.550 (1), p.149-158
Hauptverfasser:	Partosoedarso, E. R., Abrahams, T. P., Scullion, R. T., Moerschbaecher, J. M., Hornby, P. J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Decerebrate State Dilatation Dronabinol - pharmacology Esophagogastric Junction - drug effects Esophagogastric Junction - physiology Ferrets Fourth Ventricle - metabolism Fourth Ventricle - physiology Immunohistochemistry Male Manometry Muscle Relaxation - physiology Muscle, Smooth - physiology Original Pressure Receptor, Cannabinoid, CB1 - drug effects Receptor, Cannabinoid, CB1 - physiology Stomach - physiology Vagus Nerve - physiology
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