Kv1.4 channel block by quinidine: evidence for a drug-induced allosteric effect

We studied quinidine block of Kv1.4ÎN, a K + channel lacking N-type inactivation, expressed in Xenopus ooctyes. Initially, quinidine intracellularly blocked the open channel so rapidly it overlapped with activation. This rapid open channel block was reduced (non-additively) by interventions that sl...

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Veröffentlicht in:	The Journal of physiology 2003-01, Vol.546 (2), p.387-401
Hauptverfasser:	Wang, Shimin, Morales, Michael J., Qu, Yu‐Jie, Bett, Glenna C. L., Strauss, Harold C., Rasmusson, Randall L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Allosteric Regulation Amino Acid Sequence - genetics Amino Acid Substitution Animals Dose-Response Relationship, Drug Female Kv1.4 Potassium Channel Lysine Molecular Sequence Data Mutation - physiology Oocytes Original Potassium Channel Blockers - pharmacology Potassium Channels - drug effects Potassium Channels - genetics Potassium Channels, Voltage-Gated Quinidine - administration & dosage Quinidine - pharmacology Time Factors Tyrosine Xenopus laevis
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