A Versatile Synthetic Dimerizer for the Regulation of Protein--Protein Interactions

The use of low molecular weight organic compounds to induce dimerization or oligomerization of engineered proteins has wide-ranging utility in biological research as well as in gene and cell therapies. Chemically induced dimerization can be used to activate intracellular signal transduction pathways...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1997-09, Vol.94 (20), p.10618-10623
Hauptverfasser:	Amara, Jane F., Clackson, Tim, Rivera, Victor M., Guo, Tao, Keenan, Terence, Natesan, Sridaran, Pollock, Roy, Yang, Wu, Courage, Nancy L., Holt, Dennis A., Gilman, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Biochemistry Biological Sciences Carrier Proteins - metabolism Cell Line Cell lines Dimerization DNA-Binding Proteins - metabolism Drug interactions fas Receptor - metabolism Gene Expression Regulation Genes Heat-Shock Proteins - metabolism Humans Kinetics Molecular biology Molecules Monomers Plasmids Proteins Proteins - genetics Proteins - metabolism Reporter genes Tacrolimus Binding Proteins Transcription factors Transcriptional Activation
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